Mostafa Gamal A E, Al-Dosseri Abdullah S, Al-Badr Abdullah A
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Profiles Drug Subst Excip Relat Methodol. 2020;45:199-474. doi: 10.1016/bs.podrm.2019.10.007. Epub 2019 Dec 18.
A comprehensive profile of piroxicam including the nomenclatures, formulae, elemental composition, appearance, uses and applications. The methods which were utilized for the preparation of the drug substance and their respective schemes are outlined. The physical characteristics of the drug including the ionization constant, solubility, x-ray powder diffraction pattern, differential scanning calorimetry, thermal behavior and spectroscopic studies are described. The methods which were used for the analysis of the drug substance in bulk drug and/or in pharmaceutical formulations including the compendial, spectrophotometric, electrochemical and the chromatographic methods are reported. The stability, toxicity, pharmacokinetics, bioavailability, drug evaluation, comparison, in addition to compiled reviews on the drug substance are involved. Finally, more than four hundred and fifty references are listed at the end of this profile.
吡罗昔康的全面概述，包括命名法、分子式、元素组成、外观、用途及应用。概述了用于制备原料药的方法及其各自的方案。描述了该药物的物理特性，包括电离常数、溶解度、X射线粉末衍射图谱、差示扫描量热法、热行为和光谱研究。报告了用于分析原料药及/或药物制剂中药物的方法，包括药典法、分光光度法、电化学法和色谱法。还涉及该原料药的稳定性、毒性、药代动力学、生物利用度、药物评价、比较以及汇编综述。最后，本概述末尾列出了四百五十多篇参考文献。
