Al-Badr Abdullah A
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Profiles Drug Subst Excip Relat Methodol. 2022;47:149-326. doi: 10.1016/bs.podrm.2021.10.005. Epub 2021 Dec 23.
A comprehensive profile of danazol describing the nomenclatures, formulae, elemental composition, appearance, uses and applications is presented. The profile contains the method which was utilized for the preparation of the drug substance and its respective scheme is outlined. The physical characteristics of the drug including the solubility, X-ray powder diffraction pattern, differential scanning calorimetry, thermal behavior and spectroscopic studies are described. The methods which were used for the analysis of the drug substance in bulk drug and/or in pharmaceutical formulations including the compendial, spectrophotometric, electrochemical and the chromatographic methods are reported. The stability, toxicity, pharmacokinetics, bioavailability, drug evaluation and monitoring, comparisons, pharmacology, in addition to several compiled reviews on the drug substance which were involved. Finally, two hundred and seventy-nine references are listed at the end of this profile.
本文介绍了达那唑的综合概况，包括其命名法、分子式、元素组成、外观、用途及应用。该概况包含了制备原料药所采用的方法，并概述了相应的方案。描述了该药物的物理特性，包括溶解度、X射线粉末衍射图谱、差示扫描量热法、热行为和光谱研究。报告了用于分析原料药及/或药物制剂中该药物的方法，包括药典法、分光光度法、电化学法和色谱法。此外，还涉及该原料药的稳定性、毒性、药代动力学、生物利用度、药物评价与监测、比较、药理学以及若干汇编综述。最后，本概况末尾列出了279篇参考文献。
