Ceballos-Garzon Andrés, Wintaco-Martínez Luz M, Velez Norida, Hernandez-Padilla Catalina, De la Hoz Alejandro, Valderrama-Beltrán Sandra Liliana, Alvarez-Moreno Carlos A, Pape Patrice Le, Ramírez Juan David, Parra-Giraldo Claudia M
Unidad de Proteómica y Micosis Humanas, Grupo de Enfermedades Infecciosas Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia.
Grupo de Investigación en Enfermedades Infecciosas, Unidad de Infectología, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Facultad de Medicina, Bogotá, Colombia.
J Glob Infect Dis. 2020 Feb 19;12(1):16-20. doi: 10.4103/jgid.jgid_74_19. eCollection 2020 Jan-Mar.
The present article describes retrospectively a case of a patient with chronic mucocutaneous candidiasis (CMC) who presented recurrent infection since he was 6 months old. We obtained 16 isolates recovered during a 4-year period. Our purpose was to determinate the susceptibility, genotyping, and the pathogenicity profile in all the isolates.
Sixteen were isolated from a 25-year-old male with several recurrent fungal infections admitted to Hospital. The isolates were recovered during 4 years from a different anatomical origin. We typified them by multilocus sequence typing, also we evaluated susceptibility to fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, caspofungin, and amphotericin B by microdilution method and we also test the pathogenic capacity in the model.
Genotyping of all clinical isolates showed the persistence of the same diploid sequence type (DST). Isolates changed their susceptibility profile over time, but there were no significant statistical differences in pathogenicity.
Herein, a persistent clonal isolates of (DST 918) in a patient with CMC, showed changes in its susceptibility profile after several antifungal treatments acquiring gradual resistance to the azole drugs, which did not affect their pathogenicity.
本文回顾性描述了一例慢性黏膜皮肤念珠菌病（CMC）患者的病例，该患者自6个月大起就反复感染。我们获取了在4年期间分离出的16株菌株。我们的目的是确定所有分离株的药敏性、基因分型和致病性特征。
从一名因多次反复真菌感染入院的25岁男性身上分离出16株菌株。这些分离株在4年期间从不同的解剖部位获取。我们通过多位点序列分型对它们进行分型，还通过微量稀释法评估了它们对氟康唑、伊曲康唑、伏立康唑、泊沙康唑、艾沙康唑、卡泊芬净和两性霉素B的药敏性，并且我们也在模型中测试了它们的致病能力。
所有临床分离株的基因分型显示相同的二倍体序列类型（DST）持续存在。分离株的药敏性特征随时间发生了变化，但致病性方面没有显著的统计学差异。
在此，一名CMC患者中持续存在的克隆分离株（DST 918），在经过多次抗真菌治疗后其药敏性特征发生了变化，逐渐获得了对唑类药物的耐药性，但这并未影响其致病性。
Zotero 插件
