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艾滋病病毒护理连续统一体结果:埃塞俄比亚能否实现联合国艾滋病规划署的90-90-90目标?

HIV Care continuum Outcomes: Can Ethiopia Meet the UNAIDS 90-90-90 Targets?

作者信息

Gesesew Hailay Abrha, Ward Paul, Woldemichael Kifle, Mwanri Lillian

机构信息

Public Health, Flinders University, Adelaide, Australia.

Epidemiology, Jimma University, Jimma, Ethiopia.

出版信息

Ethiop J Health Sci. 2020 Mar;30(2):179-188. doi: 10.4314/ejhs.v30i2.5.

Abstract

BACKGROUND

Ethiopia has pledged to the UNAIDS 90-90-90 framework. However, the achievements of these UNAIDS targets are not assessed in Southwest Ethiopia. Using HIV care and treatment outcomes as surrogate markers, we assessed all targets.

METHODS

Complex surrogate makers were used to assess the HIV care continuum outcomes using antiretroviral therapy data in Jimma University Teaching Hospital. Early HIV diagnosis was a surrogate marker to measure the first 90. Numbers of people on HIV treatment and who have good adherence were used to measure the second 90. To measure the third 90, we used immunological success that was measured using numbers of CD4 counts, clinical success using WHO clinical stages and treatment success using immunological and clinical successes.

RESULTS

In total, 8172 patients were enrolled for HIV care from June 2003 to March 2015. For the diagnosis target, the prevalence of early HIV diagnosis among patients on ART was 35% (43% among children and 33.3% among adults). For the treatment target, 5299(65%) received ART of which 1154(22%) patients lost to follow-up or defaulted from ART treatment, and 1015(19%) patients on treatment transferred out to other sites. In addition, 17% had fair or good adherence. Finally, 81% had immunological success, 80% had clinical success and 66% treatment success.

CONCLUSIONS

The study revealed that Southwest Ethiopia achieved 35%, 65% and 66% of the first, second and third UNAIDS targets, a very far performance from achieving the target. These highlight further rigorous interventions to improve outcome of HIV continuum of care.

摘要

背景

埃塞俄比亚已承诺实施联合国艾滋病规划署的90-90-90框架。然而,埃塞俄比亚西南部地区尚未对这些联合国艾滋病规划署目标的达成情况进行评估。我们以艾滋病护理和治疗结果作为替代指标,对所有目标进行了评估。

方法

利用吉姆马大学教学医院的抗逆转录病毒治疗数据,采用复杂的替代指标来评估艾滋病护理连续过程的结果。早期艾滋病诊断是衡量第一个90%目标的替代指标。接受艾滋病治疗且依从性良好的人数用于衡量第二个90%目标。为衡量第三个90%目标,我们使用通过CD4细胞计数数量衡量的免疫成功、通过世界卫生组织临床分期衡量的临床成功以及通过免疫和临床成功衡量的治疗成功。

结果

2003年6月至2015年3月期间,共有8172名患者登记接受艾滋病护理。对于诊断目标,接受抗逆转录病毒治疗的患者中早期艾滋病诊断的患病率为35%(儿童中为43%,成人中为33.3%)。对于治疗目标,5299名(65%)患者接受了抗逆转录病毒治疗,其中1154名(22%)患者失访或中断了抗逆转录病毒治疗,1015名(19%)接受治疗的患者转至其他地点。此外,17%的患者依从性一般或良好。最后,81%的患者获得免疫成功,80%的患者获得临床成功,66%的患者获得治疗成功。

结论

该研究表明,埃塞俄比亚西南部地区实现了联合国艾滋病规划署第一个、第二个和第三个目标的35%、65%和66%,与实现目标的差距甚远。这些结果凸显了进一步采取严格干预措施以改善艾滋病护理连续过程结果的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a17/7060392/97e28b3af8f4/EJHS3002-0179Fig1.jpg

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