Nasution Ali Napiah, Aziz Hermansyah, Tjong Djong Hon, Zein Rahmiana
Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia.
Department of Tropical Medicine, Faculty of Medicine, University of Prima Indonesia, Medan, Indonesia.
Open Access Maced J Med Sci. 2019 Dec 13;7(23):3950-3954. doi: 10.3889/oamjms.2019.786. eCollection 2019 Dec 15.
Cd (II) ion is a heavy metal that has a toxic ability in the human body. P. macrocarpa has been used as anticancer, Diabetes Mellitus and antimicrobe because it consists of flavonoid, steroid, and tannin.
The purpose of this study was to investigate the effectiveness of P. macrocarpa fruits extract as an antidote for the toxicity of Cd (II) in the liver of experimental rats.
The experimental laboratory was done by using 9 female of Wistar rats (Rattus novergicus) that divided into 3 groups with the age between 2.5-3 months and weight between 133-160 grams. The first group was a control given distilled water and a normal diet. The second group was given antidote 5 mL of P. macrocarpa fruit extract x BW/200 g dosage for 7 days and induced by 1000 mg/L of Cd (II) ion with dosage of 1 mL x BW/200 g. The third group was given 1000 mg/L Cd (II) ion only of 1 mL x BW/200 g. After 5 hours, the blood sample was taken for analysis of MDA, SGOT, and SGPT.
As the result of experimental rats exposed with Cd (II) ion, there are significant decreasing of all the observed parameters including MAD, SGOT and SGPT with percentage 71.5%, 72.1%, and 93.6% respectively.
The rats given with the antidote of Phaleria macrocarpa flesh fruit were able to protect the liver from damage due to exposure to Cd (II) as seen from the decrease in liver function enzyme parameters namely SGOT and SGPT.
镉（II）离子是一种在人体中具有毒性的重金属。大果木鳖果已被用作抗癌、治疗糖尿病和抗菌药物，因为它含有黄酮类、甾体和单宁。
本研究旨在探讨大果木鳖果提取物作为实验大鼠肝脏中镉（II）毒性解毒剂的有效性。
实验在9只雌性Wistar大鼠（褐家鼠）上进行，将其分为3组，年龄在2.5 - 3个月之间，体重在133 - 160克之间。第一组为对照组，给予蒸馏水和正常饮食。第二组给予5毫升大果木鳖果提取物解毒剂，剂量为体重/200克，持续7天，并以1000毫克/升的镉（II）离子诱导，剂量为1毫升/体重/200克。第三组仅给予1000毫克/升的镉（II）离子，剂量为1毫升/体重/200克。5小时后，采集血样分析丙二醛（MDA）、谷草转氨酶（SGOT）和谷丙转氨酶（SGPT）。
实验大鼠暴露于镉（II）离子后，所有观察参数包括丙二醛、谷草转氨酶和谷丙转氨酶均显著下降，下降百分比分别为71.5%、72.1%和93.6%。
从肝功能酶参数谷草转氨酶和谷丙转氨酶的下降可以看出，给予大果木鳖果肉果实解毒剂的大鼠能够保护肝脏免受镉（II）暴露的损害。
