Hourani Wafa, Alexander Stephen P H
School of Life Sciences, Medical School, University of Nottingham, Nottingham, UK.
Brain Neurosci Adv. 2018 Jun 19;2:2398212818783908. doi: 10.1177/2398212818783908. eCollection 2018 Jan-Dec.
Endocannabinoids have been identified to have roles in numerous physiological and pathological processes. Largely due to the association of the effects of administration on mental states, the CNS impact of the endocannabinoid system has been the most intensively studied. Here, we provide a brief summary of the endocannabinoid system, comprising the receptors and the multiple endogenous lipid derivatives which activate them, as well as the enzymes which control the levels of these lipid derivatives. We identify pharmacological tools which may be used to interrogate the endocannabinoid system, as well as current and future options to exploit the system in the clinic.
内源性大麻素已被证实参与众多生理和病理过程。很大程度上由于其给药对精神状态的影响，内源性大麻素系统对中枢神经系统的影响得到了最为深入的研究。在此，我们对内源性大麻素系统进行简要概述，该系统包括受体、激活这些受体的多种内源性脂质衍生物，以及控制这些脂质衍生物水平的酶。我们还确定了可用于研究内源性大麻素系统的药理学工具，以及目前和未来在临床上利用该系统的选择。
