Grant Seth G N
Genes to Cognition Programme, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Brain Neurosci Adv. 2018 Nov 15;2:2398212818810685. doi: 10.1177/2398212818810685. eCollection 2018 Jan-Dec.
Synapses are the hallmark of brain complexity and have long been thought of as simple connectors between neurons. We are now in an era in which we know the full complement of synapse proteins and this has created an existential crisis because the molecular complexity far exceeds the requirements of most simple models of synaptic function. Studies of the organisation of proteome complexity and its evolution provide surprising new insights that challenge existing dogma and promote the development of new theories about the origins and role of synapses in behaviour. The postsynaptic proteome of excitatory synapses is a structure with high molecular complexity and sophisticated computational properties that is disrupted in over 130 brain diseases. A key goal of 21st-century neuroscience is to develop comprehensive molecular datasets on the brain and develop theories that explain the molecular basis of behaviour.
突触是大脑复杂性的标志，长期以来一直被视为神经元之间的简单连接。我们现在所处的时代，已经了解了突触蛋白的完整组成，这引发了一场生存危机，因为分子复杂性远远超过了大多数简单突触功能模型的要求。对蛋白质组复杂性及其进化的组织研究提供了惊人的新见解，这些见解挑战了现有教条，并促进了关于突触在行为中的起源和作用的新理论的发展。兴奋性突触的突触后蛋白质组是一种具有高分子复杂性和复杂计算特性的结构，在130多种脑部疾病中会受到破坏。21世纪神经科学的一个关键目标是建立关于大脑的全面分子数据集，并发展能够解释行为分子基础的理论。
