School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Anal Bioanal Chem. 2020 Sep;412(24):5925-5933. doi: 10.1007/s00216-020-02545-4. Epub 2020 Mar 12.
Therapeutic drug monitoring is used in the clinical setting in the optimisation of dosages to overcome inter-patient pharmacokinetic variability, increasing efficacy whilst reducing toxicity. Imatinib is a tyrosine kinase inhibitor, displaying large variations in plasma concentrations that impact therapeutic success. As a result, imatinib has been the focus in the development of innovative techniques, aimed at its quantification in plasma. Liquid chromatography coupled with tandem mass spectrometry is currently the gold standard; however, cost and availability of the equipment limit its wider application in clinical settings. Recent advances in the field have shown Raman spectroscopy and electrochemistry to be key techniques for the development of promising analytical tools. This article reviews the latest advances towards less costly, more portable solutions that can be used at the point of care. Graphical abstract.
治疗药物监测在临床环境中用于优化剂量以克服患者间药代动力学变异性，提高疗效同时降低毒性。伊马替尼是一种酪氨酸激酶抑制剂，其在血浆浓度方面表现出很大的变化，这影响了治疗的成功。因此，伊马替尼一直是开发创新技术的重点，旨在对其进行定量检测。液相色谱-串联质谱法目前是金标准；然而，设备的成本和可用性限制了其在临床环境中的更广泛应用。该领域的最新进展表明，拉曼光谱和电化学是开发有前途的分析工具的关键技术。本文综述了朝着更经济、更便携的解决方案的最新进展，这些解决方案可以在护理点使用。
