Bersano Anna, Scelzo Emma, Pantoni Leonardo, Morotti Andrea, Erbetta Alessandra, Chiapparini Luisa, Vitali Paolo, Giaccone Giorgio, Caroppo Paola, Catania Marcella, Obici Laura, Di Fede Giuseppe, Gatti Laura, Tinelli Francesca, Di Francesco Jacopo C, Piazza Fabrizio, Ferrarese Carlo, Gasparini Massimo, Adobbati Laura, Bianchi-Marzoli Stefania, Tremolada Gemma, Sacco Simona, Mancuso Michelangelo, Zedde Maria Luisa, Godani Massimiliano, Lanfranconi Silvia, Pareyson Davide, Di Girolamo Marco, Motto Cristina, Charidimou Andreas, Boulouis Gregoire, Parati Eugenio A
Cerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
"Luigi Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Neurol Sci. 2020 Aug;41(8):2193-2200. doi: 10.1007/s10072-020-04306-8. Epub 2020 Mar 12.
Cerebral amyloid angiopathy (CAA) is one of the major types of cerebral small vessel disease, and a leading cause of spontaneous intracerebral hemorrhage and cognitive decline in elderly patients. Although increasingly detected, a number of aspects including the pathophysiology, the clinical and neuroradiological phenotype, and the disease course are still under investigation. The incomplete knowledge of the disease limits the implementation of evidence-based guidelines on patient's clinical management and the development of treatments able to prevent or reduce disease progression. The SENECA (SEarchiNg biomarkErs of Cerebral Angiopathy) project is the first Italian multicenter cohort study aimed at better defining the disease natural history and identifying clinical and neuroradiological markers of disease progression. By a multidisciplinary approach and the collection of a large and well-phenotyped series and biorepository of CAA patients, the study is ultimately expected to improve the diagnosis and the knowledge of CAA pathophysiological mechanisms.
脑淀粉样血管病（CAA）是脑小血管病的主要类型之一，也是老年患者自发性脑出血和认知功能下降的主要原因。尽管其检出率日益增加，但包括病理生理学、临床和神经放射学表型以及病程等多个方面仍在研究中。对该疾病的了解不全面限制了基于证据的患者临床管理指南的实施以及能够预防或减缓疾病进展的治疗方法的开发。SENECA（脑淀粉样血管病生物标志物研究）项目是意大利首个多中心队列研究，旨在更好地界定该疾病的自然史，并识别疾病进展的临床和神经放射学标志物。通过多学科方法以及收集大量具有良好表型的CAA患者系列和生物样本库，该研究最终有望改善CAA的诊断以及对其病理生理机制的认识。
