Division of Cardiology, University of Arizona Sarver Heart Center, Tucson, USA.
Division of Cardiology, Department of Medicine, Loma Linda University Medical Center, 112345 Anderson St. SP1637, Loma Linda, CA, 92354, USA.
Am J Cardiovasc Drugs. 2020 Dec;20(6):549-558. doi: 10.1007/s40256-020-00401-5.
Amiodarone is an effective antiarrhythmic medication frequently used in practice for both ventricular and atrial arrhythmias. Though classified as a class III antiarrhythmic, it affects all phases of the cardiac action potential. However, the drug has several side effects, including thyroid abnormalities, pulmonary fibrosis, and transaminitis, for which routine monitoring is recommended. It also interacts with several medications, such as warfarin, simvastatin, and atorvastatin, and many HIV antiretroviral medications. Given the common use of this medication in medical practice, it is vital that clinicians understand the indications, contraindications, dosing, side effects, and interactions of this medication. A thorough understanding of these topics is essential for clinicians to ensure safe and effective use of amiodarone.
胺碘酮是一种有效的抗心律失常药物，在实践中常用于治疗室性和房性心律失常。尽管它被归类为 III 类抗心律失常药物，但它会影响心脏动作电位的所有阶段。然而，该药物有几种副作用，包括甲状腺异常、肺纤维化和转氨血症，因此建议进行常规监测。它还与几种药物相互作用，如华法林、辛伐他汀和阿托伐他汀，以及许多 HIV 抗逆转录病毒药物。鉴于该药物在医学实践中的广泛使用，临床医生了解该药物的适应证、禁忌证、剂量、副作用和相互作用至关重要。临床医生深入了解这些问题对于确保胺碘酮的安全有效使用至关重要。
