Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Center of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Mol Genet Genomic Med. 2020 May;8(5):e1187. doi: 10.1002/mgg3.1187. Epub 2020 Mar 12.
For better application in human forensic cases and population genetics research, it is imperative to investigate the genetic characteristics of Guanzhong Han population using enhanced Y-chromosomal short tandem repeats (Y-STR) detecting system with higher discriminating power than previous ones.
In this study, 38 Y-STRs were profiled in 430 unrelated Chinese Han male individuals from Guanzhong region of Shaanxi Province, Northwest China, using the Yfiler™ Platinum PCR Amplification Kit. Haplotype frequencies and forensic parameters were calculated. Comprehensive population comparisons with geographically/ethnically different populations in China and other worldwide countries were performed.
A total of 422 different haplotypes were observed with the overall haplotype diversity (HD), discriminatory power (DC) and haplotype match probability (HMP) were 0.9999, 0.9814, and 0.0024, respectively. Guanzhong Han showed genetically affinity with Han ethnicity from Shanxi and Henan provinces, while far distant from Tibetan populations.
This study offered a unique insight into Guanzhong Han population, the 38 Y-STRs included in the the Yfiler™ Platinum system are highly polymorphic and informative and can be used for forensic practice and human genetic research.
为了更好地应用于人类法医案例和群体遗传学研究，使用比以往更具鉴别力的增强型 Y 染色体短串联重复序列（Y-STR）检测系统来研究关中汉族人群的遗传特征势在必行。
本研究采用 Yfiler™ Platinum PCR 扩增试剂盒，对来自中国西北陕西省关中地区的 430 名无关汉族男性个体的 38 个 Y-STR 进行了分析。计算了单倍型频率和法医参数。与中国不同地理/种族和其他世界范围内的人群进行了全面的群体比较。
共观察到 422 种不同的单倍型，总体单倍型多样性（HD）、鉴别力（DC）和单倍型匹配概率（HMP）分别为 0.9999、0.9814 和 0.0024。关中汉族与山西和河南的汉族具有遗传亲缘关系，而与藏族人群则相距甚远。
本研究深入了解了关中汉族人群，Yfiler™ Platinum 系统中包含的 38 个 Y-STR 具有高度多态性和信息量，可用于法医学实践和人类遗传学研究。
