Li Lu-Yao, Fan Sheng-Gui, Gong Hui, Fan Xing, Wang De-Chun, Li Neng-Xiu, Jia Fu-Quan
Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
The Judicial Authentication Center, Wuwei Public Security Bureau, Wuwei, 733000, China.
Curr Med Sci. 2023 Feb;43(1):184-190. doi: 10.1007/s11596-022-2664-7. Epub 2022 Dec 22.
Y-Chromosomal short tandem repeat polymorphism (Y-STR) analysis plays an indispensable role in the identification of male individuals, population genetics, and biogeographic research. While profiles of many populations based on Y-STR markers in human genomes are ample, haplotype data for the Wuwei Han are still scarce.
In this study, 2180 unrelated Wuwei Han male individuals residing in Gansu Province, China were collected and genotyped using the novel Microreader™ 40Y Plus ID system. Phylogenetic relationship reconstructions, multidimensional scaling (MDS), and heatmap analysis were performed based on the genetic distance (Rst) values between our studied population and other populations of the Ymax module in the Y-STR Haplotype Reference Database (YHRD).
A total of 2129 unique haplotypes were obtained, and the haplotype diversity (HD) and discrimination capacity (DC) for the Wuwei Han were 0.9999 and 0.9931, respectively.
Our results demonstrate that the Wuwei Han population had intimate genetic relationships with East Asians, especially the geographically close Han populations. Overall, this Y-Chromosomal assay gives valuable information about paternal lineages in male individual tracking and genealogical database construction.
Y染色体短串联重复序列多态性（Y-STR）分析在男性个体识别、群体遗传学和生物地理学研究中发挥着不可或缺的作用。虽然基于人类基因组中Y-STR标记的许多群体的图谱丰富，但武威汉族的单倍型数据仍然稀缺。
在本研究中，收集了居住在中国甘肃省的2180名无关的武威汉族男性个体，并使用新型Microreader™ 40Y Plus ID系统进行基因分型。基于我们研究的群体与Y-STR单倍型参考数据库（YHRD）中Ymax模块的其他群体之间的遗传距离（Rst）值，进行系统发育关系重建、多维尺度分析（MDS）和热图分析。
共获得2129个独特的单倍型，武威汉族的单倍型多样性（HD）和鉴别能力（DC）分别为0.9999和0.9931。
我们的结果表明，武威汉族群体与东亚人，特别是地理上相近的汉族群体有密切的遗传关系。总体而言，这种Y染色体检测方法为男性个体追踪和系谱数据库建设中的父系谱系提供了有价值的信息。
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