红细胞膜多不饱和脂肪酸与中老年人群代谢综合征的发生有关：一项 8.8 年的前瞻性研究。

Erythrocyte Membrane Polyunsaturated Fatty Acids Are Associated with Incidence of Metabolic Syndrome in Middle-Aged and Elderly People-An 8.8-Year Prospective Study.

机构信息

Department of Epidemiology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.

The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

出版信息

J Nutr. 2020 Jun 1;150(6):1488-1498. doi: 10.1093/jn/nxaa039.

DOI:10.1093/jn/nxaa039

PMID:32167145

Abstract

BACKGROUND

The total and specific types of polyunsaturated fatty acids (PUFAs) related to metabolic syndrome (MetS) remain inconsistent.

OBJECTIVE

We assessed the association of erythrocyte n-3 and n-6 PUFAs with MetS and the components of MetS in a cohort population.

METHODS

This prospective analysis included 2754 participants (aged 40-75 y) from the Guangzhou Nutrition and Health Study (2008-2019) in China. Erythrocyte PUFAs at baseline were measured using gas chromatography. MetS was assessed every 3 y according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria. Multivariable Cox proportional hazard models were used to evaluate HRs and 95% CIs.

RESULTS

We identified 716 incident cases of MetS. The primary analyses showed that the HRs (95% CIs) of MetS (tertile 3 versus 1) were 0.67 (0.56, 0.80) for n-3 PUFAs and 0.70 (0.58, 0.85) for n-6 PUFAs (all Ps trend <0.001). The secondary outcomes showed that, higher erythrocyte very-long-chain (VLC) PUFAs [20:3n-3, docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), arachidonic acid (ARA), and 22:4n-6], but lower α-linolenic acid (ALA) and γ-linolenic acid (GLA), tended to be associated with lower incidences of MetS and its components; among individual MetS components, the associations of PUFAs were more pronounced for hypertriglyceridemia (HTG) and hypertension, followed by low high-density lipoproten (HDL) cholesterol. Significantly higher concentrations of n-3 PUFAs (total, DPA, and DHA) and n-6 PUFAs (total, ARA, and 22:4) were observed in participants with improved (versus progressed) status of MetS (all Ps trend ≤0.003).

CONCLUSION

This study reveals that higher erythrocyte VLC n-3 and n-6 PUFAs, but lower 18-carbon PUFAs (ALA and GLA), are associated with lower risks of MetS components (HTG, hypertension, and low HDL cholesterol) and thereby lower MetS incidence in Chinese adults.

摘要

背景

与代谢综合征（MetS）相关的多不饱和脂肪酸（PUFAs）的总量和具体类型仍不一致。

目的

我们评估了红细胞 n-3 和 n-6 PUFAs 与队列人群中 MetS 及其成分的相关性。

方法

本前瞻性分析包括来自中国广州营养与健康研究（2008-2019 年）的 2754 名参与者（年龄 40-75 岁）。使用气相色谱法测量基线时的红细胞 PUFAs。根据更新的国家胆固醇教育计划成人治疗小组 III 标准，每 3 年评估一次 MetS。多变量 Cox 比例风险模型用于评估 HRs 和 95%CI。

结果

我们确定了 716 例 MetS 新发病例。主要分析表明，MetS（三分位 3 与 1）的 HR（95%CI）分别为 n-3 PUFAs 的 0.67（0.56，0.80）和 n-6 PUFAs 的 0.70（0.58，0.85）（所有 Ptrend<0.001）。次要结局表明，红细胞长链（VLC）PUFAs[20:3n-3、二十二碳五烯酸（DPA）、二十二碳六烯酸（DHA）、花生四烯酸（ARA）和 22:4n-6]浓度较高，但 α-亚麻酸（ALA）和 γ-亚麻酸（GLA）浓度较低，与 MetS 及其成分的发生率较低有关；在个别 MetS 成分中，PUFAs 与高甘油三酯血症（HTG）和高血压的相关性更为显著，其次是低高密度脂蛋白（HDL）胆固醇。与 MetS 状态（进展或改善）相比，参与者的 n-3 PUFAs（总、DPA 和 DHA）和 n-6 PUFAs（总、ARA 和 22:4）浓度显著升高（所有 Ptrend≤0.003）。