Veterans Affairs Medical Center, Mather, CA, USA.
American River College, CA, USA.
Horm Mol Biol Clin Investig. 2020 Mar 13;41(2):hmbci-2019-0070. doi: 10.1515/hmbci-2019-0070.
Background Metabolic syndrome (MetS) continues to be a significant problem globally, affecting nearly 35% of adults in the USA. Whilst there is no ideal biomarker that captures this disorder, high sensitivity C-reactive protein (hsCRP) appears to be most widely accepted. We examined the ratios between neutrophils (PMNs) and monocytes to high-density lipoprotein (HDL)-cholesterol and adiponectin, two anti-inflammatory proteins, in patients with nascent MetS without the confounding of diabetes, atherosclerotic cardiovascular diseases (ASCVD), smoking or lipid therapy to determine if they were also valid biomarkers of MetS. Materials and methods Patients with nascent MetS (n = 58) and matched controls (n = 44) were recruited from Sacramento County. Fasting blood samples were obtained for complete blood counts, basic metabolic panel, lipid profile, insulin and adiponectin. Ratios of PMNs and monocytes to HDL-C and adiponectin were calculated and compared statistically. Results The PMN:HDL-C, monocyte:HDL-C, PMN:adiponectin and monocyte:adiponectin ratios were significantly increased in patients with MetS and increased with increasing severity of MetS. Receiver operating characteristic (ROC) curve analysis showed that both the PMN:HDL-C and monocyte:HDL-C areas under the curve (AUCs) significantly added to the CRP AUC. Also both the ratios correlated with cardio-metabolic features of MetS, hsCRP and insulin resistance. Conclusions Our data indicates that ratios of neutrophils and monocytes to HDL-C are significantly increased in patients with nascent MetS and both ratios appear to be better predictors of MetS than hsCRP alone. These important preliminary findings need to be confirmed in large prospective databases.
代谢综合征（MetS）在全球范围内仍然是一个严重的问题，影响了美国近 35%的成年人。虽然目前还没有一种理想的生物标志物能够捕捉到这种疾病，但高敏 C 反应蛋白（hsCRP）似乎是最被广泛接受的。我们研究了初发代谢综合征患者中性粒细胞（PMN）与单核细胞与高密度脂蛋白（HDL）-胆固醇和脂联素的比值，这两种抗炎蛋白，以确定它们是否也是代谢综合征的有效生物标志物，而不考虑糖尿病、动脉粥样硬化性心血管疾病（ASCVD）、吸烟或脂质治疗的混杂因素。
从萨克拉门托县招募了初发代谢综合征（n = 58）和匹配对照（n = 44）患者。采集空腹血样进行全血细胞计数、基本代谢谱、血脂谱、胰岛素和脂联素检测。统计分析 PMN 和单核细胞与 HDL-C 和脂联素的比值。
代谢综合征患者的 PMN：HDL-C、单核细胞：HDL-C、PMN：脂联素和单核细胞：脂联素比值明显升高，并随着代谢综合征严重程度的增加而增加。受试者工作特征（ROC）曲线分析显示，PMN：HDL-C 和单核细胞：HDL-C 的曲线下面积（AUC）均显著增加了 CRP 的 AUC。这两个比值与代谢综合征的心血管代谢特征、hsCRP 和胰岛素抵抗也相关。
我们的数据表明，初发代谢综合征患者中性粒细胞和单核细胞与 HDL-C 的比值明显升高，这两个比值似乎比 hsCRP 单独预测代谢综合征的效果更好。这些重要的初步发现需要在大型前瞻性数据库中得到证实。
