Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science, Kerman University of Medical Sciences, Kerman, Iran.
Endocrinol Diabetes Metab. 2023 Mar;6(2):e407. doi: 10.1002/edm2.407. Epub 2023 Jan 27.
Metabolic syndrome (MetS) is a global public health concern. Chronic inflammation plays a role in MetS; haematological inflammatory parameters can be used as MetS predicting factors.
Hereditary and environmental factors play an important role in the development of MetS. This study aimed to determine the relationship between haematological parameters and MetS in the adult population of southeastern Iran, Kerman.
This cross-sectional study was a sub-analysis of 1033 subjects who participated in the second phase of the Kerman Coronary Artery Disease Risk Factor Study (KERCADRS). Metabolic syndrome was diagnosed according to Adult Treatment Panel III (ATP III) definition. Pearson correlation coefficient was used to investigate the relationship between haematological parameters with age and components of metabolic syndrome. The role of WBC, neutrophil, lymphocyte and monocyte in predicting metabolic syndrome was evaluated using the receiver operating characteristic (ROC) curve.
White blood cell (WBC) and its subcomponent cells count, red cell distribution width (RDW), monocyte to HDL ratio (MHR) and Neutrophil to HDL ratio (NHR) had a significant positive correlation with the severity of MetS. The cut-off value of WBC was 6.1 (×10 /μL), the sensitivity was 70%, the specificity was 52.9% for females, the cut-off value of WBC was 6.3 (×10 /μL), the sensitivity was 68.2% and the specificity was 46.7%, for males.
WBC and its subcomponent count, RDW, MHR and NHR parameters are valuable biomarkers for further risk appraisal of MetS in adults. These markers are helpful in early diagnoses of individuals with MetS.
代谢综合征（MetS）是一个全球性的公共健康问题。慢性炎症在 MetS 中起作用；血液炎症参数可用作 MetS 的预测因素。
遗传和环境因素在 MetS 的发展中起重要作用。本研究旨在确定伊朗东南部克尔曼成年人血液参数与 MetS 之间的关系。
这是一项横断面研究，是参加克尔曼冠状动脉疾病风险因素研究（KERCADRS）第二阶段的 1033 名受试者的亚分析。根据成人治疗小组 III（ATP III）的定义诊断代谢综合征。Pearson 相关系数用于研究血液参数与年龄和代谢综合征成分之间的关系。使用受试者工作特征（ROC）曲线评估白细胞（WBC）、中性粒细胞、淋巴细胞和单核细胞在预测代谢综合征中的作用。
白细胞（WBC）及其亚组分细胞计数、红细胞分布宽度（RDW）、单核细胞与高密度脂蛋白比值（MHR）和中性粒细胞与高密度脂蛋白比值（NHR）与 MetS 的严重程度呈显著正相关。WBC 的截断值为 6.1（×10 /μL），女性的敏感性为 70%，特异性为 52.9%，WBC 的截断值为 6.3（×10 /μL），敏感性为 68.2%，特异性为 46.7%，男性。
WBC 及其亚组分计数、RDW、MHR 和 NHR 参数是评估成年人 MetS 进一步风险的有价值的生物标志物。这些标志物有助于早期诊断 MetS 个体。
