Pan Xiaoyu, Zhang Xueqing, Ban Jiangli, Yue Lin, Ren Lin, Chen Shuchun
Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
J Inflamm Res. 2023 Apr 27;16:1853-1865. doi: 10.2147/JIR.S406102. eCollection 2023.
Neutrophils and high-density lipoprotein cholesterol (HDL-C) are significantly linked to cardiovascular disease (CVD). This study investigates the correlation of neutrophil count to HDL-C ratio (NHR) with cardiac ultrasound parameters and cardiovascular risk in healthy populations.
Firstly, NHR was calculated based on neutrophils and HDL-C. Then, the differences in basic clinical characteristics and cardiac ultrasound parameters were compared between the high and low NHR groups, males and females. Subsequently, cardiovascular risk was predicted according to the Chinese 10-year ischemic cardiovascular disease (ICVD) risk assessment tool for people aged 35-60 years. Finally, the correlation between NHR and cardiac ultrasound parameters and cardiovascular risk was calculated.
A total of 3020 healthy participants, 1879 males and 1141 females, were included. Participants in the high NHR group had significantly increased Aorta (AO), Left Atrium (LA), Right Atrium (RA), Right Ventricle (RV), End Systolic Diameter of Left Ventricle (ESD), End Diastolic Diameter of Left Ventricle (EDD), Main Pulmonary Artery (MPA), Right Ventricular Outflow Tract (RVOT), Interventricular Septum (IVS), Left Ventricular Posterior Wall (LVPW), and cardiovascular risk and decreased E/A values compared to those in the low NHR group. The same results were found in males participants compared to females. A total of 1670 participants underwent ICVD risk assessment tool. Cardiovascular risk was significantly higher in those with high NHR and in males than in those with low NHR and in females. Correlation analysis showed that NHR was positively correlated with AO, LA, RA, RV, ESD, EDD, MPA, RVOT, IVS, LVPW and cardiovascular risk, and negatively correlated with E/A values.
Our study demonstrates that NHR is significantly associated with cardiac ultrasound parameters and cardiovascular risk in healthy populations. NHR may serve as a useful indicator for the early diagnosis and treatment of cardiovascular disease among healthy populations.
中性粒细胞与高密度脂蛋白胆固醇（HDL-C）与心血管疾病（CVD）显著相关。本研究调查了健康人群中中性粒细胞计数与HDL-C比值（NHR）与心脏超声参数及心血管风险的相关性。
首先，根据中性粒细胞和HDL-C计算NHR。然后，比较高NHR组和低NHR组、男性和女性之间的基本临床特征和心脏超声参数差异。随后，根据中国35-60岁人群10年缺血性心血管疾病（ICVD）风险评估工具预测心血管风险。最后，计算NHR与心脏超声参数及心血管风险之间的相关性。
共纳入3020名健康参与者，其中男性1879名，女性1141名。与低NHR组相比，高NHR组参与者的主动脉（AO）、左心房（LA）、右心房（RA）、右心室（RV）、左心室收缩末期内径（ESD）、左心室舒张末期内径（EDD）主肺动脉（MPA）、右心室流出道（RVOT）、室间隔（IVS）、左心室后壁（LVPW）及心血管风险显著增加，E/A值降低。男性参与者与女性参与者结果相同。共有1670名参与者接受了ICVD风险评估工具评估。高NHR者和男性的心血管风险显著高于低NHR者和女性。相关性分析显示，NHR与AO、LA、RA、RV、ESD、EDD、MPA、RVOT、IVS、LVPW及心血管风险呈正相关，与E/A值呈负相关。
我们的研究表明，NHR与健康人群的心脏超声参数及心血管风险显著相关。NHR可能作为健康人群心血管疾病早期诊断和治疗的有用指标。
