Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Robert Debré Hospital, University Hospital of Reims.
Department of Infectious Diseases, University Hospital of Martinique, Martinique, INSERM UMR, Toulouse.
AIDS. 2020 Jun 1;34(7):1057-1063. doi: 10.1097/QAD.0000000000002519.
Psoriasis is a T-cell-mediated inflammatory disease with genetic factors involved in its etiopathogenesis. In non-HIV populations, HLA-B57:01 has been associated with a higher risk of psoriasis. The aim of this study was to investigate demographic and immunovirological characteristics associated with psoriasis, and to assess whether HLA-B57:01 is associated with psoriasis among people living with HIV (PLHIV) followed in a large French multicenter Dat'AIDS cohort.
All PLHIV followed up from January 2000 to December 2018 with an available result for HLA-B57:01 were included. Logistic regression models were used to identify associations between psoriasis (outcome variable) and explanatory variables.
Among 31 076 PLHIV, the overall prevalence of psoriasis and HLA-B57:01 were 2.25 and 4.73%, respectively and varied according to ethnicity. By multivariate analysis, male gender [OR 1.81 (95% CI 1.46-2.24), P < 10], positive HLA-B57:01 [OR 2.66 (95% CI 2.12-3.33), P < 10], nadir CD4 cell count less than 200 cells/μl [OR 1.41 (95% CI 1.19-1.67), P < 10] and positive HCV serology [OR 1.45 (95% CI 1.20-1.76), P < 10] were significantly associated with a higher risk of psoriasis. Being born in West and Central Africa [OR 0.15 (95% CI 0.10-0.25), P < 10], the Caribbean islands [OR 0.14 (95% CI 0.05-0.45), P = 0.0008] or Latin America [OR 0.31 (95% CI 0.14-0.69), P = 0.004] was associated with a lower risk of psoriasis compared with patients born in mainland France.
PLHIV carrying HLA-B57:01 have around a three-fold increased risk of psoriasis. This association might provide a possible explanation for the observed differences in psoriasis prevalence between ethnic groups.
银屑病是一种由 T 细胞介导的炎症性疾病，其发病机制涉及遗传因素。在非 HIV 人群中，HLA-B57:01 与银屑病的风险增加有关。本研究旨在探讨与银屑病相关的人口统计学和免疫病毒学特征，并评估 HLA-B57:01 是否与在法国大型多中心 Dat'AIDS 队列中接受治疗的 HIV 感染者（PLHIV）中的银屑病有关。
纳入了 2000 年 1 月至 2018 年 12 月期间有 HLA-B57:01 检测结果的所有 PLHIV。使用逻辑回归模型确定银屑病（因变量）与解释变量之间的关联。
在 31076 名 PLHIV 中，银屑病和 HLA-B57:01 的总体患病率分别为 2.25%和 4.73%，且因种族而异。多变量分析显示，男性（OR 1.81[95%CI 1.46-2.24]，P<10）、HLA-B57:01 阳性（OR 2.66[95%CI 2.12-3.33]，P<10）、CD4 细胞计数低值（OR 1.41[95%CI 1.19-1.67]，P<10）和 HCV 血清学阳性（OR 1.45[95%CI 1.20-1.76]，P<10）与银屑病风险增加显著相关。出生于西非和中非（OR 0.15[95%CI 0.10-0.25]，P<10）、加勒比岛屿（OR 0.14[95%CI 0.05-0.45]，P=0.0008）或拉丁美洲（OR 0.31[95%CI 0.14-0.69]，P=0.004）与出生于法国本土的患者相比，银屑病风险降低。
携带 HLA-B57:01 的 PLHIV 患银屑病的风险增加了约三倍。这种关联可能为观察到的不同种族间银屑病患病率差异提供了一个可能的解释。
