Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
AIDS. 2020 Jun 1;34(7):1081-1087. doi: 10.1097/QAD.0000000000002517.
To estimate the proportion of US HIV-positive men who report a male HIV-negative/unknown status (HIV-discordant) sexual partner taking preexposure prophylaxis (PrEP), and the use of multiple HIV prevention strategies within partnerships.
The Medical Monitoring Project is a complex sample survey of US adults with diagnosed HIV.
We used data collected during June 2016 to May 2018 among sexually active HIV-positive men who had at least one HIV-discordant male partner (N = 1871) to estimate the weighted prevalence of reporting at least one partner taking PrEP. Among HIV-discordant partnerships (N = 4029), we estimated PrEP use, viral suppression among HIV-positive partners, and condomless anal sex. We evaluated significant (P < 0.05) differences between groups using prevalence ratios with predicted marginal means.
Twenty-eight percent of sexually active HIV-positive MSM reported at least one HIV-discordant male partner taking PrEP. Twenty percent of HIV-discordant partners were reported to be taking PrEP; 73% were taking PrEP or the HIV-positive partner was virally suppressed. PrEP use was lower among black and Hispanic partners compared with white partners (12% and 19% vs. 27%). Fewer black than white MSM were in partnerships in which PrEP was used or the HIV-positive partner had sustained viral suppression (69% vs. 77%). Condomless anal intercourse was more prevalent in partnerships involving PrEP use and in partnerships involving either PrEP use or sustained viral suppression among the HIV-positive partner.
PrEP use was reported among one in five partners, with disparities between black and white partners. Increasing PrEP use and decreasing racial/ethnic disparities could reduce disparities in HIV incidence and help end the US HIV epidemic.
估计报告存在男性 HIV 阴性/未知感染状况(HIV 不一致)性伴侣接受暴露前预防(PrEP)的美国 HIV 阳性男性比例,以及在伴侣关系中使用多种 HIV 预防策略的情况。
医疗监测项目是一项针对美国成年 HIV 感染者的复杂样本调查。
我们使用 2016 年 6 月至 2018 年 5 月期间收集的活跃性 HIV 阳性男性的数据,这些男性至少有一名 HIV 不一致的男性伴侣(N=1871),以估计报告至少有一名伴侣正在接受 PrEP 的加权患病率。在 HIV 不一致的伴侣关系中(N=4029),我们估计了 PrEP 的使用情况、HIV 阳性伴侣的病毒抑制情况和无保护肛交情况。我们使用预测边际均值的患病率比评估了组间差异的统计学意义(P<0.05)。
28%的活跃性 HIV 阳性男男性行为者报告至少有一名 HIV 不一致的男性伴侣正在接受 PrEP。20%的 HIV 不一致伴侣报告正在接受 PrEP;73%的伴侣正在接受 PrEP 或 HIV 阳性伴侣的病毒得到抑制。与白人伴侣相比,黑人(12%)和西班牙裔(19%)伴侣的 PrEP 使用率较低。与白人男男性行为者相比,黑人男男性行为者参与使用 PrEP 或 HIV 阳性伴侣维持病毒抑制的伴侣关系的比例较低(69%比 77%)。在涉及 PrEP 使用的伴侣关系中,以及在涉及 PrEP 使用或 HIV 阳性伴侣持续病毒抑制的伴侣关系中,无保护肛交更为普遍。
报告了五分之一的伴侣使用 PrEP,黑人和白人伴侣之间存在差异。增加 PrEP 的使用并减少种族/民族差异可以减少 HIV 发病率的差异,并有助于结束美国的 HIV 流行。