（1→5）-连接的β-D-呋喃半乳糖苷在青霉属和曲霉属物种的细胞外多糖中具有免疫显性。

(1----5)-linked beta-D-galactofuranosides are immunodominant in extracellular polysaccharides of Penicillium and Aspergillus species.

作者信息

Notermans S, Veeneman G H, van Zuylen C W, Hoogerhout P, van Boom J H

机构信息

National Institute of Public Health and Environment Hygiene, Bilthoven, The Netherlands.

出版信息

Mol Immunol. 1988 Oct;25(10):975-9. doi: 10.1016/0161-5890(88)90003-x.

DOI:10.1016/0161-5890(88)90003-x

PMID:3216871

Abstract

Aspergillus and Penicillium species produce extracellular polysaccharides which are immunologically active. Methyl beta-D-galactofuranoside interferes with the reaction between the polysaccharide antigens and the antibodies raised in rabbits. Of the different interlinked dimers of beta-D-galactofuranosides (1----2; 1----3; 1----5; 1----6) the (1----5) interlinked beta-D-galactofuranoside gave the highest inhibition. An increasing inhibitory effect of di-, tri-, tetra-, penta-, hexa-, and heptamer of (1----5) interlinked beta-D-galactofuranosides was observed. It was noticed that the penta-, hexa- and heptamer of (1----5) interlinked beta-D-galactofuranosides were able to link antibodies raised against the extracellular polysaccharides produced by Penicillium species. The tetramer molecule was able to neutralize the binding of antibodies, which are naturally present in human sera, to the polysaccharides produced by Penicillium and Aspergillus species.

摘要

曲霉属和青霉属物种产生具有免疫活性的细胞外多糖。β-D-呋喃半乳糖苷甲酯会干扰多糖抗原与兔体内产生的抗体之间的反应。在β-D-呋喃半乳糖苷的不同相互连接的二聚体（1→2；1→3；1→5；1→6）中，（1→5）相互连接的β-D-呋喃半乳糖苷产生的抑制作用最强。观察到（1→5）相互连接的β-D-呋喃半乳糖苷的二聚体、三聚体、四聚体、五聚体、六聚体和七聚体的抑制作用不断增强。值得注意的是，（1→5）相互连接的β-D-呋喃半乳糖苷的五聚体、六聚体和七聚体能够连接针对青霉属物种产生的细胞外多糖而产生的抗体。四聚体分子能够中和人血清中天然存在的抗体与青霉属和曲霉属物种产生的多糖的结合。