Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Federico II University Hospital, via Pansini 5, 80131 Naples, Italy.
Gastroenterology Unit, Department of Clinical Medicine and Surgery, Federico II University Hospital, via Pansini 5, 80131 Naples, Italy.
Nutrients. 2020 Mar 11;12(3):746. doi: 10.3390/nu12030746.
This study aimed to assess health related quality of life (HRQoL) in adult patients with Crohn's disease (CD), considering disease severity and gender differences, and also its relationship with nutritional status. Consecutive adult patients aged 18-65 years with CD were recruited. Disease activity was clinically defined by the Crohn's Disease Activity Index (CDAI) in active and quiescent phases. HRQoL was evaluated using the validated short form (SF)-36 questionnaire for the Italian population. Additionally, anthropometry, bioimpedance analysis, and handgrip-strength (HGS) were performed. Findings showed that 135 patients (79 men and 56 women) were included, having a mean age of 38.8 ± 14 years and a BMI of 23.2 ± 3.7 kg/m. Overall, active CD patients had a lower perception of their QoL compared to those clinically quiescent, while gender differences emerged mostly in the quiescent group. Interestingly, HRQoL was significantly associated with many nutritional variables, and muscle strength was the main predictor Therefore, HRQoL is perceived lower in active compared to quiescent patients, but women experienced poorer QoL than men, especially in the quiescent phase. Finally, higher QoL scores were found in subjects being in clinical remission phase with a preserved muscle function. However, further studies are still required to verify these findings
本研究旨在评估成人克罗恩病（CD）患者的健康相关生活质量（HRQoL），同时考虑疾病严重程度和性别差异，以及其与营养状况的关系。连续招募了 18-65 岁的成年 CD 患者。活动期和缓解期的临床 CD 活动指数（CDAI）用于定义疾病活动度。使用经过验证的意大利人群短式（SF）-36 问卷评估 HRQoL。此外，还进行了人体测量学、生物阻抗分析和握力（HGS）测试。结果显示，共纳入 135 例患者（79 名男性和 56 名女性），平均年龄为 38.8±14 岁，BMI 为 23.2±3.7kg/m²。总体而言，与临床缓解的患者相比，活动期 CD 患者对其生活质量的感知较差，而性别差异主要出现在缓解组中。有趣的是，HRQoL 与许多营养变量显著相关，肌肉力量是主要的预测因素。因此，与缓解期患者相比，活动期患者的 HRQoL 较低，但女性的生活质量较男性差，尤其是在缓解期。最后，在具有肌肉功能保留的临床缓解期患者中发现了更高的 QoL 评分。然而，仍需要进一步的研究来验证这些发现。
