Cai Menghan, Zhou Xiaoxi, Wang Songna, Huang Xuan, Chen Wei, Chen Yiling, Huang Litao, Yan Yan, Zhu Yizhun, Ye Li
School of Pharmacy and Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau SAR 999078, China.
Department of Biological Medicines, Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai 201103, China.
Int J Mol Sci. 2025 Sep 4;26(17):8617. doi: 10.3390/ijms26178617.
CD93 is a highly glycosylated transmembrane glycoprotein with key functional domains, including a C-type lectin-like domain (CTLD) and epidermal growth factor (EGF)-like domains. Primarily expressed in endothelial cells (ECs), CD93 regulates critical physiological processes such as angiogenesis, cell adhesion, migration, and apoptotic cell clearance through interactions with ligands like multimerin-2 (MMRN2) and insulin-like growth factor-binding protein 7 (IGFBP7). Aberrant CD93 expression has been observed in various pathological conditions, including inflammation, cardiovascular diseases, autoimmune disorders, and cancer. Notably, CD93 is overexpressed in tumor-associated blood vessels, which is associated with poor prognosis and advanced disease stages. Targeting the CD93 signaling pathway has the potential to improve tumor vascular function and enhance the efficacy of immunotherapy, making it a promising therapeutic target. This review summarizes the current understanding of CD93's structure, function, and disease mechanisms, providing a framework for further research and clinical translation in related fields.
CD93是一种高度糖基化的跨膜糖蛋白，具有关键功能结构域，包括C型凝集素样结构域（CTLD）和表皮生长因子（EGF）样结构域。CD93主要在内皮细胞（ECs）中表达，通过与多聚蛋白-2（MMRN2）和胰岛素样生长因子结合蛋白7（IGFBP7）等配体相互作用，调节血管生成、细胞粘附、迁移和凋亡细胞清除等关键生理过程。在包括炎症、心血管疾病、自身免疫性疾病和癌症在内的各种病理条件下，均观察到CD93表达异常。值得注意的是，CD93在肿瘤相关血管中过度表达，这与预后不良和疾病晚期相关。靶向CD93信号通路有可能改善肿瘤血管功能并增强免疫治疗效果，使其成为一个有前景的治疗靶点。本综述总结了目前对CD93的结构、功能和疾病机制的认识，为相关领域的进一步研究和临床转化提供了框架。
