Department of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.
J Coll Physicians Surg Pak. 2020 Mar;30(3):250-253. doi: 10.29271/jcpsp.2020.03.250.
To investigate the value of preoperative blood tests in predicting lymph node metastasis in colon cancer patients undergoing surgery.
Obervational study.
General Surgery Department, Bolu Abant Izzet Baysal University Medicine School, Turkey, between December 2012 and December 2018.
In 171 colon cancer patients, preoperative inflammatory markers such as albumin, C-reactive protein (CRP), platelet, neutrophil-to-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) counts were determined.
The present study albumin, CRP and NLR values were also not significantly different between the groups. PLR (p=0.008) and PLT (p=0.039) were significantly different between the lymph node groups. ROC analysis was performed for PLT and PLR for the prediction of lymph node metastasis (Group 2 and 3). Accuracy for PLT was 0.623 and accuracy for PLR was 0.65. A PLT value >321.5 was found to be 63.7% sensitive and 68.6% specific in predicting lymph node metastasis. A PLR value >155.81 was 70% sensitive and 41% specific for predicting lymph node metastasis.
The platelet counts and PLR values are important in predicting lymph node metastasis in colon cancer, preoperatively. Platelet and PLR values may be more specific and sensitive in predicting preoperative lymph node metastasis in colon cancer patients.
探讨术前血液检查在预测结肠癌手术患者淋巴结转移中的价值。
观察性研究。
土耳其博卢阿邦特伊泽特贝萨尔大学医学院普通外科系，2012 年 12 月至 2018 年 12 月。
在 171 例结肠癌患者中，测定了术前炎症标志物，如白蛋白、C 反应蛋白（CRP）、血小板、中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）计数。
本研究白蛋白、CRP 和 NLR 值在淋巴结组之间也无显著差异。PLR（p=0.008）和 PLT（p=0.039）在淋巴结组之间差异显著。对 PLT 和 PLR 进行了 ROC 分析，以预测淋巴结转移（第 2 组和第 3 组）。PLT 的准确性为 0.623，PLR 的准确性为 0.65。PLT 值>321.5 预测淋巴结转移的敏感性为 63.7%，特异性为 68.6%。PLR 值>155.81 预测淋巴结转移的敏感性为 70%，特异性为 41%。
血小板计数和 PLR 值在预测结肠癌淋巴结转移中具有重要意义，术前即可进行。血小板和 PLR 值在预测结肠癌患者术前淋巴结转移方面可能更具特异性和敏感性。
