作为寄生虫免疫原性分子配体的药物：一种分离靶抗原的方法。
Drugs as ligands of immunogenic molecules in parasites: an approach to the isolation of target-antigens.
作者信息
Bout D, Dupas H, Capron M, Tran-Van-Ky P, Capron A
出版信息
J Immunol Methods. 1977;15(1):1-8. doi: 10.1016/0022-1759(77)90011-4.
PMID:321693
Abstract
Schistosomicide drugs are used as ligands to isolate the target antigens of schistosome by affinity chromatography. Anti-target antigens immune sera produced in rabbit permit their localization on the parasite using immunofluorescence. Target antigens of some drugs determine a relatively high immunoprotection in rat or mouse schistosomiasis infection.
摘要
杀血吸虫药物被用作配体，通过亲和色谱法分离血吸虫的靶抗原。在兔体内产生的抗靶抗原免疫血清可利用免疫荧光法在寄生虫上定位这些抗原。某些药物的靶抗原在大鼠或小鼠血吸虫感染中能产生较高的免疫保护作用。
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