Laboratory of Molecular Cell Biology, Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8421, Japan.
Laboratory of Molecular Cell Biology, Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8421, Japan.
Semin Cell Dev Biol. 2020 Dec;108:47-54. doi: 10.1016/j.semcdb.2020.02.013. Epub 2020 Mar 11.
Lipid droplets (LDs) are not an inert storage of excessive lipids, but play various roles in cellular lipid metabolism. Autophagy involves several mechanisms for the degradation of cellular components, and is related to many aspects of lipid metabolism. LD and autophagic membranes often distribute in proximity, but their relationship is complex. LDs can be degraded by autophagy, but LDs are also generated as a result of autophagy or support the execution of autophagy. Moreover, several proteins crucial for autophagy were shown to affect different aspects of LD formation. This article aims to categorize this multifaceted and seemingly entangled LD-autophagy relationship and to discuss unresolved issues.
脂滴（LDs）不是多余脂质的惰性储存库，而是在细胞脂质代谢中发挥多种作用。自噬涉及细胞成分降解的几种机制，与脂质代谢的许多方面有关。LD 和自噬膜经常靠近分布，但它们的关系很复杂。LD 可以通过自噬降解，但 LD 也是自噬的结果或支持自噬的执行而产生的。此外，一些对自噬至关重要的蛋白质被证明会影响 LD 形成的不同方面。本文旨在对这种多方面且看似复杂的 LD-自噬关系进行分类，并讨论尚未解决的问题。
