DeFrance J F, Sikes R W, Gottesfeld Z
J Neurochem. 1983 Jan;40(1):291-3. doi: 10.1111/j.1471-4159.1983.tb12685.x.
The nucleus accumbens is an important telencephalic region, which is the target limbic and mesolimbic pathways. Because of an ongoing physiological study of the effects of dopamine, we wanted to determine regional differences of dopamine and norepinephrine concentrations in the nucleus. As determined by radioenzymatic assays, dopamine levels were not significantly different in the anterior-posterior dimension, averaging approximately 187 ng dopamine/mg protein. Substantial amounts of norepinephrine were found throughout the nucleus, but the levels were significantly higher in the caudal portions of the nucleus, being approximately 4.5 times higher than in the anterior portions.
伏隔核是一个重要的端脑区域，是边缘系统和中脑边缘系统通路的靶点。由于正在进行关于多巴胺作用的生理学研究，我们想确定伏隔核中多巴胺和去甲肾上腺素浓度的区域差异。通过放射酶法测定，多巴胺水平在前后维度上没有显著差异，平均约为187 ng多巴胺/毫克蛋白质。在整个伏隔核中都发现了大量的去甲肾上腺素，但尾侧部分的水平明显更高，约为前侧部分的4.5倍。
