Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National University (HBNI), Mumbai, India.
Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National University (HBNI), Mumbai, India.
Oral Oncol. 2020 May;104:104627. doi: 10.1016/j.oraloncology.2020.104627. Epub 2020 Mar 10.
Early oral cavity cancers comprise a favorable entity, amenable to clinical staging and single modality treatment. Surgery typically forms the mainstay of treatment and should ideally address both the primary and the neck in all cases. Careful attention must be paid to reconstruction and rehabilitation of such patients. Radical radiotherapy mainly in the form of brachytherapy can achieve excellent disease related and functional outcomes in a carefully chosen subset of patients. Increasingly, a subset of patients is being recognized, who harbor single or multiple adverse features on histopathology and may therefore benefit from escalation of adjuvant therapy. This review discusses the management of early oral cavity squamous carcinomas (Early OSCCs) in detail and highlights the dilemmas and controversies faced in the management of the same.
早期口腔癌是一种预后良好的实体肿瘤，适合临床分期和单一治疗模式。手术通常是治疗的主要方法，在所有情况下，都应理想地处理原发灶和颈部。必须仔细注意此类患者的重建和康复。根治性放疗主要以近距离放疗的形式，在精心选择的一部分患者中，可以实现极好的疾病相关和功能结果。越来越多的患者被认为具有单一或多种组织病理学上的不良特征，因此可能受益于辅助治疗的升级。本文详细讨论了早期口腔鳞状细胞癌（Early OSCCs）的治疗，并强调了在处理这些肿瘤时面临的困境和争议。
