Nakahara H, Kitamura R, Shirasuna K
Department of Oral and Maxillofacial Surgery, Osaka Teishin Hospital, Japan.
J Oral Maxillofac Surg. 1995 Dec;53(12):1455-7. doi: 10.1016/0278-2391(95)90676-2.
Primary malignant melanoma of the oral cavity is rare. The incidence of oral melanoma constitutes between 0.2% and 8.0% of all melanomas, although higher percentages are reported in Japanese and other nonwhite races. In contrast, squamous cell carcinoma is the most common malignant neoplasm in the oral region. Multiple cancers may develop independently over the course of time in one organ, or double cancers may develop separately in different organs. Both types of cancer are collectively referred to as multiple primary cancers. The simultaneous occurrence of two histologically distinct primary malignancies in the same organ is extremely rare. We present a case of simultaneous malignant melanoma in association with squamous cell carcinoma of the oral cavity.
口腔原发性恶性黑色素瘤较为罕见。口腔黑色素瘤的发病率占所有黑色素瘤的0.2%至8.0%，不过据报道，在日本人和其他非白种人中这一比例更高。相比之下，鳞状细胞癌是口腔区域最常见的恶性肿瘤。多种癌症可能在一个器官的病程中独立发生，或者双原发癌可能在不同器官中分别发生。这两种类型的癌症统称为多原发性癌症。在同一器官中同时出现两种组织学上不同的原发性恶性肿瘤极为罕见。我们报告一例口腔同时发生恶性黑色素瘤与鳞状细胞癌的病例。
