清醒和麻醉犬丘脑及额叶皮质的局部血流情况。

Local blood flow in the thalamus and frontal cortex in alert and narcotized dogs.

作者信息

Kaasik A E, Asser T K, Ul'st M V

机构信息

Department of Neurology and Neurosurgery, State University of Tartu.

出版信息

Neurosci Behav Physiol. 1988 Sep-Oct;18(5):384-7. doi: 10.1007/BF01193883.

DOI:10.1007/BF01193883

PMID:3216988

Abstract

The magnitude of the local blood flow in the thalamus and cerebral cortex is studied on 22 sexually mature nonpedigree dogs. Mean values of local blood flow are obtained in alert animals, and the effect of narcosis (nitrous oxide) on the local cerebral blood flow is studied. The mean local blood flow in alert dogs is found to be 84.8 +/- 2.9 ml/100 g/min in the cerebral cortex and 68.7 +/- 1.6 ml/100 g/min in the thalamus. Insignificant fluctuations are found during a dynamic recording of the local blood flow during 7 days. Under narcosis (70% nitrous oxide) the local blood flow decreases 3-12%. According to the findings, nitrous oxide narcosis does not significantly affect the brain circulation, so that it is suitable for an experimental study of the latter.

摘要

对22只性成熟的非纯种犬的丘脑和大脑皮质局部血流量进行了研究。在清醒动物中获得局部血流量的平均值，并研究麻醉（氧化亚氮）对局部脑血流量的影响。发现清醒犬大脑皮质的平均局部血流量为84.8±2.9 ml/100 g/分钟，丘脑为68.7±1.6 ml/100 g/分钟。在7天的局部血流量动态记录期间发现波动不明显。在麻醉（70%氧化亚氮）下，局部血流量减少3-12%。根据研究结果，氧化亚氮麻醉对脑循环无显著影响，因此适用于脑循环的实验研究。