Seki H, Yoshimoto T, Ogawa A, Suzuki J
Stroke. 1983 Jan-Feb;14(1):46-50. doi: 10.1161/01.str.14.1.46.
Using the canine thalamic infarction model, we have investigated the effects of 10 ml/kg of 20% mannitol on the hemodynamics of the ischemic brain. Mannitol was found to cause an increase in rCBF, but it is not marked in animals with severe ischemic foci. Increases were statistically significant in the animals with moderate ischemia. Increases in rCBF due to mannitol administration lasted for about 1 hour, as did the rise in serum osmolarity. The actual relationship between these two parameters, remains unclear.
利用犬丘脑梗死模型，我们研究了10毫升/千克20%甘露醇对缺血性脑血流动力学的影响。发现甘露醇可使局部脑血流量（rCBF）增加，但在有严重缺血灶的动物中这种增加并不明显。在中度缺血的动物中，增加具有统计学意义。静脉注射甘露醇引起的rCBF增加持续约1小时，血清渗透压升高也是如此。这两个参数之间的实际关系仍不清楚。
