Validity of cerebral blood flow measurements obtained with quantitative tracer techniques.

A great number of results for the cerebral blood flow obtained in the animal with quantitative tracer techniques have been collected from the literature. They are exposed in order to compare both normal flow values in different laboratory species, and the characteristics, accuracy and sensitivity of each technique. A dramatic overall dispersion of flow values is observed, allowing neither the flow level particular to each species to be estimated, nor the average value provided by a given technique to be found. The physiological and technological causes of such a dispersion are discussed. Several techniques seem to have limitations which even alter the interpretation of their results, and especially the origin of the local or regional blood flow results. Other techniques may be criticized from the quantitative standpoint, but give more reliable results.