Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Ophthalmology Department, Bingol Woman's Health and Children's Hospital, Bingol, Turkey.
Graefes Arch Clin Exp Ophthalmol. 2020 Jun;258(6):1217-1225. doi: 10.1007/s00417-020-04643-6. Epub 2020 Mar 13.
The aim of this study was to image the radial peripapillary capillary vessel densities (RPCvds) of the affected eyes and fellow unaffected eyes of individuals with unilateral pseudoexfoliation syndrome (PES) using optical coherence tomography angiography (OCTA) and to compare the RPCvds with those of normal age-matched individuals.
The eyes were divided into three groups: the pseudoexfoliative material (PXM)-positive eyes of patients with clinically unilateral PES (study eyes), the fellow eyes of the PXM-positive patients (fellow eyes), and the eyes of healthy patients (control eyes). Those patients with glaucomatous findings, including peripapillary hemorrhaging, cupping, notching, focal thinning of the neuroretinal rim, or intraocular pressure readings greater than 21 mmHg, were excluded from the study. The RPCvd (%), peripapillary retinal nerve fiber layer (RNFL) thickness (μm), cup/disc area ratio, rim area (mm), disc area (mm), and cup volume (mm) were automatically calculated via OCTA.
This cross-sectional comparative prospective study included 128 eyes of 88 patients: 40 PXM-positive eyes, 40 fellow eyes, and 48 control eyes. The RPCvds and RNFL thicknesses in the peripapillary region were significantly lower in the study eyes than in the fellow eyes and the control eyes (p = 0.011 and p = 0.011, p = 0.009 and p = 0.004, respectively). There were no significant differences between the fellow eyes and the control eyes with regard to the RPCvd and RNFL values in any region (p > 0.05 for all).
Lower RPCvds could provoke capillary deficiency and deterioration of the perfusion of the optic nerve head in patients with PES.
本研究旨在使用光相干断层扫描血管造影术（OCTA）对单侧假性剥脱综合征（PES）患者受影响眼和未受影响眼的视盘周围放射状毛细血管密度（RPCvd）进行成像，并将其与正常年龄匹配个体的 RPCvd 进行比较。
将眼分为三组：患有临床单侧 PES 的患者的假性剥脱物质（PXM）阳性眼（研究眼）、PXM 阳性患者的对侧眼（对侧眼）和健康患者的眼（对照眼）。那些有青光眼发现的患者，包括视盘周围出血、杯盘比、神经视网膜边缘切迹、局部变薄或眼压读数大于 21mmHg 的患者被排除在研究之外。通过 OCTA 自动计算 RPCvd（%）、视盘周围视网膜神经纤维层（RNFL）厚度（μm）、杯/盘面积比、边缘面积（mm）、盘面积（mm）和杯体积（mm）。
这项横断面对比前瞻性研究包括 88 例患者的 128 只眼：40 只 PXM 阳性眼、40 只对侧眼和 48 只对照眼。研究眼中的 RPCvd 和视盘周围区域的 RNFL 厚度明显低于对侧眼和对照组（p=0.011 和 p=0.011，p=0.009 和 p=0.004）。在任何区域，对侧眼和对照组之间的 RPCvd 和 RNFL 值均无显著差异（p>0.05）。
较低的 RPCvd 可能导致 PES 患者毛细血管不足和视神经头灌注恶化。
