Hummingbird House Children's Hospice, 60 Curwen Tce, Chermside, Queensland, 4032, Australia.
Herston campus, Herston, Brisbane, Queensland, 4006, Australia.
Curr Oncol Rep. 2020 Mar 13;22(4):34. doi: 10.1007/s11912-020-0900-5.
Opioids are the only class of drug with the proven ability to control severe pain. The introduction of stringent opioid prescribing restrictions has inevitably impacted upon the ability of those prescribing opioids for advanced life-limited disease to practice as previously and could limit the supply of adequate pain relief to patients with cancer. This review considers the evidence that symptom management of patients with advanced cancer contributes to the "opioid problem" and whether there is adequate recognition of the risks involved.
The literature suggests that the risk of opioid abuse is low in the palliative care population as is the risk of legal consequences for doctors prescribing opioids at the end of life. However, as many patients with cancer are living longer or surviving with chronic pain, palliative care physicians must be cognisant not only of the risks of long term opioid use but also of the risk of opioid misuse. Adherence to evidence or consensus-based guidelines is necessary to avoid inappropriate prescribing. In palliative care, it is appropriate not only to exercise a reasonable degree of opioid control and surveillance, primarily for the good of society, but also to ensure that the ability to treat pain in patients with advanced malignant disease is not compromised.
阿片类药物是唯一被证实能够控制重度疼痛的药物类别。严格限制阿片类药物处方的规定不可避免地影响了为晚期生命有限疾病开具阿片类药物的医生的实践能力,并可能限制癌症患者获得足够疼痛缓解的供应。这篇综述考虑了症状管理是否有助于“阿片类药物问题”以及是否充分认识到所涉及的风险。
文献表明,在姑息治疗人群中,阿片类药物滥用的风险较低,医生在生命末期开具阿片类药物也不会面临法律后果。然而,由于许多癌症患者的寿命更长或患有慢性疼痛,姑息治疗医生不仅必须意识到长期使用阿片类药物的风险,还要意识到阿片类药物滥用的风险。为避免不适当的处方,必须遵守基于证据或共识的指南。在姑息治疗中,不仅要合理控制和监测阿片类药物,主要是为了社会的利益,还要确保治疗晚期恶性疾病患者疼痛的能力不会受到影响。