Exotic and Emerging Avian Viral Diseases Unit, US National Poultry Research Center, US Department of Agriculture, Agricultural Research Service, Athens, GA, USA.
Methods Mol Biol. 2020;2123:61-68. doi: 10.1007/978-1-0716-0346-8_5.
Antigenic cartography is a powerful method that allows for the calculation of antigenic distances between influenza viruses or sera and their positioning on a map, by quantifying raw data from hemagglutination inhibition assays. As a consequence, the antigenic drift of influenza viruses over time can be visualized in a straightforward manner. Antigenic cartography is not only useful in the research of influenza virus evolution but also in the surveillance of influenza viruses. Most importantly, antigenic cartography plays a very important role in vaccine updating decisions, since by calculating the antigenic distances between a vaccine strain and circulating strains, an informed decision can be made on whether the distances are large enough to warrant a vaccine update or not. Recent improvements in antigenic cartography calculations have significantly improved its accuracy.
抗原图谱是一种强大的方法，通过量化血凝抑制试验的原始数据，可以计算流感病毒或血清之间的抗原距离，并在地图上定位，从而直观地显示流感病毒随时间的抗原漂移。抗原图谱不仅在流感病毒进化的研究中有用，而且在流感病毒的监测中也很有用。最重要的是，抗原图谱在疫苗更新决策中起着非常重要的作用，因为通过计算疫苗株与流行株之间的抗原距离，可以做出明智的决策，即距离是否足够大，是否需要更新疫苗。抗原图谱计算的最新改进显著提高了其准确性。
