Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China.
Liver Int. 2020 May;40(5):998-1004. doi: 10.1111/liv.14435. Epub 2020 Mar 30.
The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), the pathogen of 2019 novel coronavirus disease (COVID-19), has posed a serious threat to global public health. The WHO has declared the outbreak of SARS-CoV-2 infection an international public health emergency. Lung lesions have been considered as the major damage caused by SARS-CoV-2 infection. However, liver injury has also been reported to occur during the course of the disease in severe cases. Similarly, previous studies have shown that liver damage was common in the patients infected by the other two highly pathogenic coronavirus - severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), and associated with the severity of diseases. In this review, the characteristics and mechanism of liver injury caused by SARS-CoV, MERS-CoV as well as SARS-CoV-2 infection were summarized, which may provide help for further studies on the liver injury of COVID-19.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是 2019 年新型冠状病毒病（COVID-19）的病原体，对全球公共卫生构成了严重威胁。世界卫生组织已宣布 SARS-CoV-2 感染爆发为国际公共卫生紧急事件。肺部病变被认为是 SARS-CoV-2 感染引起的主要损伤。然而，在严重病例中，也有报道称在疾病过程中会发生肝损伤。同样，先前的研究表明，感染另外两种高致病性冠状病毒——严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV）的患者中也常发生肝损伤，且与疾病的严重程度相关。在这篇综述中，总结了 SARS-CoV、MERS-CoV 以及 SARS-CoV-2 感染引起肝损伤的特征和机制，这可能有助于进一步研究 COVID-19 的肝损伤。
