Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Department of Hematology, Kawasaki Municipal Ida Hospital, Tokyo, Japan.
Transpl Infect Dis. 2020 Jun;22(3):e13278. doi: 10.1111/tid.13278. Epub 2020 May 19.
Nontuberculous mycobacteria are ubiquitous in water and soil, and the subset of rapidly growing mycobacteria species can cause severe infections in immunocompromised patients. Solid organ or hematopoietic stem cell transplantation (HSCT) recipients are known to be susceptible to infection by nontuberculous mycobacteria. The nontuberculous mycobacteria species Mycobacterium massiliense (M massiliense) has been classified as a rapidly growing mycobacteria and recognized as a pathogen causing lung and soft tissue infections in humans. However, there have been only a few reported cases of M massiliense infection after solid organ transplantation and HSCT. We herein report another case of M massiliense infection after allogeneic HSCT, which manifested as soft tissue infection, lung infection, and bacteremia.
非结核分枝杆菌广泛存在于水和土壤中，其中快速生长分枝杆菌亚群可导致免疫功能低下患者发生严重感染。实体器官或造血干细胞移植 (HSCT) 受者易感染非结核分枝杆菌。分枝杆菌种 Mycobacterium massiliense（M massiliense）已被归类为快速生长分枝杆菌，并被认为是导致人类肺部和软组织感染的病原体。然而，仅有少数报道称实体器官移植和 HSCT 后发生 M massiliense 感染。本研究报告了首例异基因 HSCT 后 M massiliense 感染病例，表现为软组织感染、肺部感染和菌血症。
