Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, Kansas.
Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla, Missouri.
J Biomed Mater Res B Appl Biomater. 2020 Oct;108(7):2765-2775. doi: 10.1002/jbm.b.34606. Epub 2020 Mar 14.
Bone cement is used extensively in orthopedics to anchor prostheses to bone and fill voids. Incorporating bioactive glass into poly(methyl methacrylate) (PMMA)-based bone cement could potentially improve its effectiveness for these tasks. This study characterizes the mechanical and degradation properties of composites containing PMMA-based bone cement and particles of borate bioactive glass designated as 13-93B3. Glass particles of size 5, 33, and 100 μm were mixed with PMMA bone cement to create composites containing 20, 30, and 40 wt % glass. Composites and a bone cement control were soaked in phosphate-buffered saline. Compressive strength, Young's modulus, weight loss, water uptake, solution pH, and ionic concentrations were measured over 21 days. The compressive strengths of composites decreased over 21 days. Average Young's moduli of the composites remained below 3 GPa. Weight loss and water uptake of specimens did not exceed 2 and 6%, respectively. Boron concentrations and pH of all solutions increased over time, with higher glass weight fractions leading to higher pH values. Results demonstrated that the composite can sustain glass degradation and ionic release without compromising short-term mechanical strength.
骨水泥在矫形外科中被广泛用于将假体固定在骨头上并填充空隙。将生物活性玻璃掺入聚甲基丙烯酸甲酯（PMMA）基骨水泥中，可能会提高其在这些任务中的效果。本研究对含有 PMMA 基骨水泥和硼酸盐生物活性玻璃颗粒（称为 13-93B3）的复合材料的力学和降解性能进行了表征。将粒径为 5、33 和 100 μm 的玻璃颗粒与 PMMA 骨水泥混合，制成玻璃含量分别为 20、30 和 40wt%的复合材料。将复合材料和骨水泥对照品浸泡在磷酸盐缓冲盐溶液中。在 21 天内测量了压缩强度、杨氏模量、失重、吸水率、溶液 pH 值和离子浓度。复合材料的压缩强度在 21 天内下降。复合材料的平均杨氏模量一直低于 3 GPa。试样的失重和吸水率均未超过 2%和 6%。所有溶液中的硼浓度和 pH 值随时间的推移而增加，较高的玻璃重量分数导致较高的 pH 值。结果表明，该复合材料可以在不影响短期机械强度的情况下，承受玻璃的降解和离子释放。
