Silva Elvio G, Kim Grace, Bakkar Rania, Bozdag Zehra, Shaye-Brown Alexandra, Loghavi Sanam, Stolnicu Simona, Hadareanu Viorel, Bulgaru Diana, Cayax Lilian Isabel, Pitalua Martha Cecilia Tuñon, Pinto Karen
The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Cedars Sinai Medical Center, Los Angeles, CA, USA.
University of Southern California, Los Angeles, CA, USA.
Ann Diagn Pathol. 2020 Jun;46:151475. doi: 10.1016/j.anndiagpath.2020.151475. Epub 2020 Feb 4.
Detailed descriptions of ovarian histology are rare. We reviewed in detail 57 cases of normal ovaries in premenopausal patients, when the ovaries are active and primordial follicles are found. We also proposed updated definitions to more clearly distinguish inclusion cysts, which do not have a known relationship with any disease process, from endosalpingiosis, a lesion closely associated with low grade serous neoplasia of the ovary. The most interesting findings were the significant variation in the histologic features including the variation in the amount and the distribution of primordial follicles, follicular cysts, and endosalpingiosis, within the ovary and between both ovaries in the same patient, the frequent presence of primordial follicles in the medulla, specifically in cases of multiple follicular cysts, and the frequent presence of endosalpingiosis. We believe that to confirm a pathologic process in the ovary, we need to become familiar with the histologic features of the normal ovary and their variations.
关于卵巢组织学的详细描述很少见。我们详细回顾了57例绝经前患者的正常卵巢病例，这些患者的卵巢处于活跃状态且可发现原始卵泡。我们还提出了更新的定义，以便更清楚地区分与任何疾病过程均无已知关联的包涵囊肿和与卵巢低级别浆液性肿瘤密切相关的输卵管内膜异位症。最有趣的发现是组织学特征存在显著差异，包括原始卵泡、滤泡囊肿和输卵管内膜异位症的数量和分布在卵巢内部以及同一患者的两侧卵巢之间均有变化，髓质中频繁出现原始卵泡，特别是在存在多个滤泡囊肿的情况下，以及输卵管内膜异位症的频繁出现。我们认为，要确认卵巢中的病理过程，我们需要熟悉正常卵巢的组织学特征及其变异情况。
