Department of Microbiology, Xiangya School of Medicine, Central South University, Changsha, 410078, Hunan, China.
Curr Allergy Asthma Rep. 2020 Mar 14;20(4):11. doi: 10.1007/s11882-020-00903-x.
Bronchial asthma is a common respiratory disease induced by immune imbalance, characterized by chronic non-specific airway inflammation and airway hyperresponsiveness (AHR). Many factors induce asthma, among which respiratory infection is the important cause. In this review, we discuss how respiratory microbes participate in the occurrence and progression of asthma via Th17/IL-17 axis.
Pathogenesis of asthma has been considered as closely related to the imbalance in number and function of Th1/Th2 in the CD4 T lymphocyte subsets. Recent studies have shown that Th17 cell and its secretory IL-17 also play an important role in AHR. Respiratory virus, bacteria, fungi, and other respiratory microbial infections can directly or indirectly induce the differentiation of Th17 cell and the production of related cytokines to induce AHR. Respiratory microbial infection can affect the TH17/IL-17A axis through a variety of mechanisms, thereby promoting the occurrence and development of asthma, and these specific mechanisms may provide new effective therapeutic ideas for asthma.
支气管哮喘是一种由免疫失衡引起的常见呼吸道疾病，其特征为慢性非特异性气道炎症和气道高反应性（AHR）。许多因素可诱发哮喘，其中呼吸道感染是重要的原因。本文通过 Th17/IL-17 轴讨论了呼吸道微生物如何参与哮喘的发生和发展。
哮喘的发病机制被认为与 CD4+T 淋巴细胞亚群中 Th1/Th2 数量和功能的失衡密切相关。最近的研究表明，Th17 细胞及其分泌的白细胞介素 17（IL-17）也在 AHR 中发挥重要作用。呼吸道病毒、细菌、真菌和其他呼吸道微生物感染可直接或间接诱导 Th17 细胞分化和相关细胞因子产生，从而诱导 AHR。呼吸道微生物感染可通过多种机制影响 TH17/IL-17A 轴，从而促进哮喘的发生和发展，这些特定机制可能为哮喘提供新的有效治疗思路。
