Gunnarsson P O, Norlén B J
Department of Pharmacokinetics, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden.
Prostate. 1988;13(4):299-304. doi: 10.1002/pros.2990130405.
The results of the present studies demonstrate that intramuscular injections of polyestradiol phosphate (PEP) produce not only considerably increased estrogen concentration in plasma but also maintain the same estrone/estradiol ratio as in normal men. Monthly injections of PEP produce persistent elevation of the plasma estradiol levels throughout the dose interval, and rising PEP doses produce proportionately increasing steady-state plasma concentrations of estradiol. The steady-state plasma concentrations of testosterone are reduced to 45, 25, and 15% of the pretreatment concentrations after treatment every fourth week with 80, 160, and 240 mg PEP, respectively.
本研究结果表明，肌肉注射磷酸聚雌二醇（PEP）不仅可使血浆中雌激素浓度显著升高，而且能维持与正常男性相同的雌酮/雌二醇比例。每月注射PEP可使整个剂量间隔内血浆雌二醇水平持续升高，且随着PEP剂量增加，血浆雌二醇稳态浓度也相应升高。分别每四周用80、160和240mg PEP治疗后，睾酮的稳态血浆浓度分别降至治疗前浓度的45%、25%和15%。
