基于挤出式 3D 打印技术制备壳聚糖导管用于软组织工程。
Chitosan ducts fabricated by extrusion-based 3D printing for soft-tissue engineering.
机构信息
Key Laboratory of Optoelectronic Materials Chemical and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China; University of Chinese Academy of Sciences, Beijing, China.
Orthopedics Department, Fujian Medical University Union Hospital, Fuzhou, China.
出版信息
Carbohydr Polym. 2020 May 15;236:116058. doi: 10.1016/j.carbpol.2020.116058. Epub 2020 Feb 21.
Three kinds of methods based on extrusion and 3D printing and different acidic solutions (formic acid (FA), acetic acid (AA), glycolic acid (GA) and lactic acid (LA)) were applied for manufacturing the CS ducts. The tensile properties and preliminary cytotoxicity were measured for selecting the optimal ratio of CS slurry. The 3D printability of CS slurry was also studied. The tensile strength, Young's modulus, and fracture strain were tested for evaluating the degree of mechanical matching to soft-tissue. The optimal solvent to CS was 30 wt.% GA solution. The CS slurry possessing shear-thinning properties was suitable for 3D printing. The tensile strength, Young's modulus, and fracture strain of the CS rods were 10.98 ± 0.61 MPa, 12.38 ± 1.19 MPa, and 146.03 ± 15.05 %, correspondingly. The CS ducts manufactured by 3D printing had an excellent mechanical matching to soft-tissue, outstanding biocompatibility and have great potential for soft-tissue restorations.
三种基于挤出和 3D 打印的方法以及不同的酸性溶液（甲酸（FA）、乙酸（AA）、乙醇酸（GA）和乳酸（LA））被用于制造 CS 导管。通过测量拉伸性能和初步细胞毒性来选择 CS 浆料的最佳比例。还研究了 CS 浆料的 3D 打印性能。通过测试拉伸强度、杨氏模量和断裂应变来评估其与软组织的机械匹配程度。CS 的最佳溶剂是 30wt.%GA 溶液。具有剪切变稀特性的 CS 浆料适合 3D 打印。CS 棒的拉伸强度、杨氏模量和断裂应变分别为 10.98±0.61MPa、12.38±1.19MPa 和 146.03±15.05%。通过 3D 打印制造的 CS 导管与软组织具有极好的机械匹配性、出色的生物相容性，在软组织修复方面具有巨大的潜力。
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