Department of Oral Implantology, School of Dentistry, Jilin University, Changchun 130021, China.
Int J Mol Sci. 2022 Jun 12;23(12):6574. doi: 10.3390/ijms23126574.
In recent years, bone tissue engineering (BTE), as a multidisciplinary field, has shown considerable promise in replacing traditional treatment modalities (i.e., autografts, allografts, and xenografts). Since bone is such a complex and dynamic structure, the construction of bone tissue composite materials has become an attractive strategy to guide bone growth and regeneration. Chitosan and its derivatives have been promising vehicles for BTE owing to their unique physical and chemical properties. With intrinsic physicochemical characteristics and closeness to the extracellular matrix of bones, chitosan-based composite scaffolds have been proved to be a promising candidate for providing successful bone regeneration and defect repair capacity. Advances in chitosan-based scaffolds for BTE have produced efficient and efficacious bio-properties via material structural design and different modifications. Efforts have been put into the modification of chitosan to overcome its limitations, including insolubility in water, faster depolymerization in the body, and blood incompatibility. Herein, we discuss the various modification methods of chitosan that expand its fields of application, which would pave the way for future applied research in biomedical innovation and regenerative medicine.
近年来，骨组织工程（BTE）作为一个多学科领域，在替代传统治疗方式（即自体移植物、同种异体移植物和异种移植物）方面显示出了相当大的潜力。由于骨骼是如此复杂和动态的结构，构建骨组织复合材料已成为指导骨生长和再生的一种有吸引力的策略。壳聚糖及其衍生物因其独特的物理化学性质而成为 BTE 的有前途的载体。具有内在的物理化学特性和接近骨骼细胞外基质的特性，基于壳聚糖的复合支架已被证明是提供成功的骨再生和缺陷修复能力的有前途的候选物。通过材料结构设计和不同的修饰，壳聚糖基支架在 BTE 方面的进展产生了高效和有效的生物特性。人们一直在努力修饰壳聚糖以克服其局限性，包括在水中的不溶性、在体内更快的解聚和血液不相容性。本文讨论了扩展壳聚糖应用领域的各种修饰方法，这将为生物医学创新和再生医学的未来应用研究铺平道路。
