Neurology section, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Department of NEUROFARBA, Section of Psychology, University of Florence, Florence, Italy.
Mult Scler Relat Disord. 2020 Jan;37:101418. doi: 10.1016/j.msard.2019.101418. Epub 2019 Sep 27.
Memory impairment is one of the most frequently and early detected impairment in multiple sclerosis (MS) patients. Several authors have argued that when a failure occurs in the retrieval of lexical information, this might be due to a reduction of the lexical pool, related to semantic memory. Here we further investigated memory alteration in MS patients, by focusing on memory distortions (i.e., false memories) for semantically-related material.
A group of 40 consecutive relapsing remitting MS (RRMS) patients and a matched control group of 40 healthy controls performed the Deese-Roediger-McDermott (DRM), a false memory task for lists of associated words.
At recall, RRMS patients reported a reduced number of false recalls for semantically-related but non-presented items (i.e., critical false recalls) compared to HCs; at recognition, RRMS patients showed a reduced level of confidence for false recognitions of critical items.
We found a reduced susceptibility to false memories in RRMS patients compared to HCs. The potential mechanisms underlying this effect are discussed in light of the alterations in the structure of semantic memory.
记忆障碍是多发性硬化症（MS）患者最常见和最早发现的障碍之一。有几位作者认为，当词汇信息的检索出现故障时，这可能是由于词汇量减少，与语义记忆有关。在这里，我们通过关注与语义相关材料的记忆扭曲（即错误记忆），进一步研究了 MS 患者的记忆改变。
一组 40 名连续的复发缓解型多发性硬化症（RRMS）患者和 40 名匹配的健康对照组完成了 Deese-Roediger-McDermott（DRM），这是一个与关联词列表相关的错误记忆任务。
在回忆时，RRMS 患者报告的语义相关但未呈现项目的错误回忆（即关键错误回忆）数量少于 HC；在识别时，RRMS 患者对关键项目的错误识别的置信度降低。
与 HC 相比，RRMS 患者的错误记忆易感性降低。在考虑语义记忆结构改变的情况下，讨论了这种效应的潜在机制。
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