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一名感染了艾滋病毒和乙型肝炎病毒的患者出现的持久性隆起性红斑的典型病例。

Exuberant case of erythema elevatum diutinum in a patient infected with HIV and hepatitis B virus.

作者信息

Hirayama Sayuri Aparecida, Pinheiro Cezar Arthur Tavares, Guarenti Isabelle Maffei, Oliveira Danise Senna

机构信息

Department of General Medicine, Teaching Hospital, Universidade Federal de Pelotas, Pelotas, RS, Brazil.

HIV/AIDS Specialized Care Service, Universidade Federal de Pelotas, Pelotas, RS, Brazil.

出版信息

An Bras Dermatol. 2020 Mar-Apr;95(2):200-202. doi: 10.1016/j.abd.2019.02.013. Epub 2020 Feb 12.

DOI:10.1016/j.abd.2019.02.013
PMID:32173140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7175035/
Abstract

Erythema elevatum diutinum is a small vessel vasculitis which is benign, rare, and chronic. It is clinically characterized by violaceous, brown, or yellowish plaques, nodules, and papules. It has been associated with autoimmune, infectious, and neoplastic processes. The following case describes a patient with hepatitis B virus and human immunodeficiency virus with CD4 count<200mm, HIV-seropositive for 16 years, and diagnosed with hepatitis B virus at the hospital. The patient was treated with oral dapsone 100mg/day, showing regression after seven months of treatment. The authors found three cases in the literature of association of erythema elevatum diutinum, human immunodeficiency virus, and hepatitis B virus.

摘要

持久性隆起性红斑是一种良性、罕见的慢性小血管炎。其临床特征为紫红色、棕色或淡黄色斑块、结节及丘疹。它与自身免疫、感染及肿瘤性病变相关。以下病例描述了一名患有乙型肝炎病毒和人类免疫缺陷病毒的患者,其CD4细胞计数<200/mm³,HIV血清学阳性16年,且在医院被诊断为乙型肝炎病毒感染。该患者接受了每日口服100mg氨苯砜的治疗,治疗七个月后病情出现好转。作者在文献中发现了三例持久性隆起性红斑、人类免疫缺陷病毒及乙型肝炎病毒相关联的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5d8/7175035/f9e16ef74366/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5d8/7175035/58998c90c26d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5d8/7175035/0f88edde16be/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5d8/7175035/2a1e2abbd419/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5d8/7175035/f9e16ef74366/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5d8/7175035/58998c90c26d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5d8/7175035/0f88edde16be/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5d8/7175035/2a1e2abbd419/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5d8/7175035/f9e16ef74366/gr4.jpg

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引用本文的文献

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Erythema elevatum diutinum - An atypical case presentation exposing the histopathological progression of disease.持久性隆起性红斑——一例非典型病例报告,揭示疾病的组织病理学进展
SAGE Open Med Case Rep. 2025 May 23;13:2050313X251343268. doi: 10.1177/2050313X251343268. eCollection 2025.

本文引用的文献

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Erythema elevatum diutinum: a case report and review of literature.持久性隆起性红斑:一例病例报告并文献复习。
Int J Dermatol. 2019 Apr;58(4):408-415. doi: 10.1111/ijd.14169. Epub 2018 Aug 3.
2
Erythema elevatum diutinum in acquired immune deficiency syndrome: Can it be an immune reconstitution inflammatory syndrome?获得性免疫缺陷综合征中的持久性隆起性红斑:它会是免疫重建炎症综合征吗?
Indian J Sex Transm Dis AIDS. 2016 Jan-Jun;37(1):81-4. doi: 10.4103/0253-7184.180287.
3
A Case of Erythema Elevatum Diutinum With Pancytopenia: Focus on Dapsone-Induced Hematologic Side Effects and Colchicine as a Safe Treatment Option.
J Drugs Dermatol. 2015 Oct;14(10):1090-2.
4
Erythema elevatum diutinum: an atypical presentation.持久性隆起性红斑:一种非典型表现。
Am J Med Sci. 2015 Apr;349(4):374-5. doi: 10.1097/MAJ.0000000000000397.
5
Nodular Erythema Elevatum Diutinum Mimicking Kaposi's Sarcoma in a Human Immunodeficiency Virus Infected Patient.一名感染人类免疫缺陷病毒的患者中,持久性隆起性红斑结节酷似卡波西肉瘤。
Indian J Dermatol. 2014 Nov;59(6):592-4. doi: 10.4103/0019-5154.143527.
6
Clinical and surgical therapeutic approach in erithema elevatum diutinum--case report.持久性隆起性红斑的临床及外科治疗方法——病例报告
An Bras Dermatol. 2013 Nov-Dec;88(6 Suppl 1):15-8. doi: 10.1590/abd1806-4841.20132150.
7
Successful surgical treatment of advanced erythema elevatum diutinum.晚期持久性隆起性红斑的成功手术治疗
Can J Plast Surg. 2010 Spring;18(1):28-30. doi: 10.1177/229255031001800111.
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Erythema elevatum diutinum as a first clinical manifestation for diagnosing HIV infection: case history.持久性隆起性红斑作为诊断HIV感染的首发临床表现:病例报告
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Erythema elevatum diutinum and HIV infection: a report of five cases.持久性隆起性红斑与HIV感染:5例报告
Br J Dermatol. 1999 Aug;141(2):335-8. doi: 10.1046/j.1365-2133.1999.02988.x.
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Erythema elevatum diutinum in human immunodeficiency virus-infected patients--report of a case and review of the literature.
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