Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
Weill Medical College, Cornell University, New York, USA.
J Dermatol Sci. 2020 Jun;98(3):146-151. doi: 10.1016/j.jdermsci.2020.03.001. Epub 2020 Mar 6.
Inflammasomes are large intracellular multi-protein signaling complexes which are responsible for the activation of inflammatory responses. Among multifarious subtypes of inflammasomes, NLRP3 has been associated with a variety of inflammatory and autoimmune skin conditions, including dermatophytosis, psoriasis, acne, urticaria and bullous pemphigoid and other different skin diseases which have been a subject of intensive investigation. NLRP3 is considered to be a sensor of microbial and other danger signals and plays a crucial role in immune responses, dysregulation of NLRP3 inflammasome activation is involved in skin diseases. With the in-depth research, targeting NLRP3 inflammasome and its downstream signaling will provide new insights into the development of future therapeutic strategies. In this review, we summarize the molecular mechanism of NLRP3 inflammasome activation as well as the current knowledge on the contribution of the NLRP3 inflammasome in infection-related, immune-mediated and autoimmune skin diseases.
炎症小体是一种大型的细胞内多蛋白信号复合物，负责激活炎症反应。在多种炎症小体亚型中，NLRP3 与多种炎症性和自身免疫性皮肤疾病有关，包括皮肤真菌病、银屑病、痤疮、荨麻疹和大疱性类天疱疮以及其他不同的皮肤疾病，这些疾病一直是深入研究的课题。NLRP3 被认为是微生物和其他危险信号的传感器，在免疫反应中起着关键作用，NLRP3 炎症小体的失调激活与皮肤疾病有关。随着深入研究，靶向 NLRP3 炎症小体及其下游信号转导将为未来治疗策略的发展提供新的见解。在这篇综述中，我们总结了 NLRP3 炎症小体激活的分子机制以及 NLRP3 炎症小体在感染相关、免疫介导和自身免疫性皮肤疾病中的作用的现有知识。
