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辛伐他汀联合运动训练治疗稳定期慢性阻塞性肺疾病合并代谢综合征的临床疗效

Clinical effect of simvastatin combined with exercise training in the treatment of stationary chronic obstructive pulmonary disease complicated with metabolic syndrome.

作者信息

Liu Jimin, Jiang Nan, Liu Tong, Luo Wei

机构信息

Pulmonary Rehabilitation Department, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.

Infection Control Office, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.

出版信息

Pak J Pharm Sci. 2020 Jan;33(1(Special)):437-440.

Abstract

The aim of this study is to observe and analyze the clinical efficacy of simvastatin combined with exercise training in the treatment of stationary chronic obstructive pulmonary disease complicated with metabolic syndrome. In this study, 180 patients who had been treated for stable chronic obstructive pulmonary disease (COPD) complicated with metabolic syndrome in our hospital were enrolled as research objects. The selected patients were randomly divided into research group receiving simvastatin combined with exercise training and control group accepting routine therapy, each containing 90 cases. The therapeutic effects of the two groups were compared. The CAT score, insulin resistance index and 6 min walking distance of the two groups were compared. The results showed that compared with the control group, the improvement effect of the research group was more obvious, and the effect was better than that of the control group, p<0.05. The levels of IL-6 (interleukin-6), IL-8 (interleukin-8) and other inflammatory factors were significantly lower in the research group than those in the control group, p<0.05. Simvastatin combined with exercise training in the treatment of stationary chronic obstructive pulmonary disease with metabolic syndrome is an effective treatment, which can significantly improve the treatment effect and help patients to achieve a higher quality of life.

摘要

本研究旨在观察和分析辛伐他汀联合运动训练治疗稳定期慢性阻塞性肺疾病合并代谢综合征的临床疗效。本研究选取我院收治的180例稳定期慢性阻塞性肺疾病(COPD)合并代谢综合征患者作为研究对象。将入选患者随机分为接受辛伐他汀联合运动训练的研究组和接受常规治疗的对照组,每组各90例。比较两组的治疗效果。比较两组的CAT评分、胰岛素抵抗指数和6分钟步行距离。结果显示,与对照组相比,研究组的改善效果更明显,效果优于对照组,p<0.05。研究组白细胞介素-6(IL-6)、白细胞介素-8(IL-8)等炎症因子水平明显低于对照组,p<0.05。辛伐他汀联合运动训练治疗稳定期慢性阻塞性肺疾病合并代谢综合征是一种有效的治疗方法,可显著提高治疗效果,帮助患者获得更高的生活质量。

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