Yukna R A, Tow H D, Carroll P B, Vernino A R, Bright R W
J Periodontol. 1977 Apr;48(4):187-93. doi: 10.1902/jop.1977.48.4.187.
The purpose of this investigation was to evaluate the clinical responses to freeze-dried skin allografts when used to correct mucogingival problems in humans. FDS was obtained by the NMRI Tissue Bank after processing by standard procedures. The recipient sites were prepared using the standard partial thickness dissection with apical periosteal separation. Rehydrated FDS was sutured into place to completely cover the recipient sites. Routine postoperative procedures were performed. Evaluations were made by means of calibrated periodontal probe measurements, Kodachromes, and radiographs preoperatively and up to 12 months postoperatively. Fourteen patients received 24 FDS allografts over a total of 56 tooth sites. All treated teeth showed a substantial increase (greater than 2 mm) in the width of the zone of keratinized gingiva at all postoperative time periods (2.88 +/- 1.57 mm at 12 months). Other findings included a mean gain of attachment of 0.40 +/- 1.08 mm, a mean decrease in recession of 0.12 +/- 0.91 mm, and mean decrease in pocket depth of 0.33 +/- 0.53 mm. Patient comfort was good, and there were no untoward sequelae, even in patients receiving multiple grafts. This study indicates that FDS allografts are an acceptable and beneficial material for treatment of mucogingival problems in humans.
本研究的目的是评估冻干皮肤同种异体移植物用于矫正人类黏膜牙龈问题时的临床反应。冻干皮肤移植物由NMRI组织库通过标准程序处理后获得。使用标准的部分厚度切开术并分离根尖骨膜来准备受植部位。将复水后的冻干皮肤移植物缝合到位，以完全覆盖受植部位。进行常规术后处理。术前及术后长达12个月通过校准的牙周探针测量、彩色反转片和X线片进行评估。14名患者在总共56个牙位接受了24次冻干皮肤移植物移植。所有治疗的牙齿在术后各时间段角化牙龈宽度均显著增加（大于2毫米）（12个月时为2.88±1.57毫米）。其他结果包括附着平均增加0.40±1.08毫米，退缩平均减少0.12±0.91毫米，牙周袋深度平均减少0.33±0.53毫米。患者舒适度良好，即使是接受多次移植的患者也没有出现不良后遗症。本研究表明，冻干皮肤移植物是治疗人类黏膜牙龈问题的一种可接受且有益的材料。
