Ouhayoun J P, Holzman S, Etienne D, Pierre C, Forest N
J Periodontol. 1983 Aug;54(8):463-9. doi: 10.1902/jop.1983.54.8.463.
Free gingival autografts still remain the most predictable method for creating attached gingiva. However, a need exists for sources of connective tissue other than the patient's own connective tissue. Yukna et al. have proposed freeze-dried skin (FDS) allografts as a substitute for gingival autografts. The purpose of the present study was to evaluate FDS allografts on humans, clinically and histologically. Ten FDS allografts and two free gingival (FG) autografts were performed on ten patients, two of them receiving both FDS and FG grafts. Clinical measurements were made before surgery, immediately after surgery and then 2 and 6 months after surgery. After 4 and 24 months, biopsies were performed on both FG and FDS grafts. Routine histologic staining was done. The results show a mean gain of attached gingiva of 0.32 mm with a range from 0 to 0.8 mm. Compared biopsies sections of FDS allografts and FG autografts show that the tissue obtained with the FDS allografts do not display the histomorphologic pattern of attached gingiva. The FDS allografts do not seem to represent a good substitute to free gingival autografts. However, they might be used successfully as a biological bandage.
游离龈自体移植仍然是形成附着龈最可预测的方法。然而，除了患者自身的结缔组织外，还需要其他结缔组织来源。尤克纳等人提出冻干皮肤（FDS）同种异体移植物可替代牙龈自体移植物。本研究的目的是从临床和组织学角度评估FDS同种异体移植物在人体上的应用。对10名患者进行了10次FDS同种异体移植和2次游离龈（FG）自体移植，其中2名患者同时接受了FDS和FG移植。在手术前、手术后立即以及术后2个月和6个月进行临床测量。在4个月和24个月后，对FG和FDS移植物进行活检。进行常规组织学染色。结果显示附着龈平均增加0.32毫米，范围为0至0.8毫米。对FDS同种异体移植物和FG自体移植物的活检切片进行比较，结果表明，通过FDS同种异体移植物获得的组织未显示出附着龈的组织形态学模式。FDS同种异体移植物似乎不是游离龈自体移植物的良好替代品。然而，它们可能成功用作生物绷带。
