McGrath P J, Stewart J W, Liebowitz M R, Markowitz J M, Quitkin F M, Klein D F, Gorman J M
New York State Psychiatric Institute, NY 10032.
Psychiatry Res. 1988 Jul;25(1):41-7. doi: 10.1016/0165-1781(88)90156-4.
Forty-seven nonmelancholic depressed outpatients were infused with sodium lactate to explore the relationship between history of panic attacks and lactate-induced panic. Lactate panic was rated without knowledge of history of panic. Fifteen of 29 patients (52%) with a history of spontaneous panic experienced panic attacks in response to lactate. Only 1 of 18 patients (6%) without a history of spontaneous panic experienced a lactate-induced panic attack--a highly significant difference. The likelihood of lactate panic was related to frequency of spontaneous panic attacks. The implications of these findings for understanding the relationship of panic attacks and depression are discussed.
47名非忧郁性抑郁症门诊患者接受了乳酸钠输注，以探究惊恐发作史与乳酸诱发惊恐之间的关系。在不知道惊恐发作史的情况下对乳酸诱发的惊恐进行评分。29名有自发惊恐史的患者中有15名（52%）对乳酸产生了惊恐发作。18名无自发惊恐史的患者中只有1名（6%）出现了乳酸诱发的惊恐发作——差异极为显著。乳酸诱发惊恐的可能性与自发惊恐发作的频率有关。本文讨论了这些发现对于理解惊恐发作与抑郁症关系的意义。
