Cowley D S, Dager S R, Dunner D L
Department of Psychiatry and Behavioural Sciences, University of Washington, Seattle 98195.
J Psychiatr Res. 1987;21(3):243-8. doi: 10.1016/0022-3956(87)90025-2.
Sodium lactate infusion provokes panic attacks in panic disorder patients but not in normal controls. We have previously shown that patients who develop panic disorder during a major depressive episode are similar to panic disorder patients in their rate of panic attacks with lactate. In the present pilot study, nine patients with major depression without panic attacks underwent lactate infusions. These patients differed significantly from panic disorder patients but not from controls in their response to lactate. This argues for the specificity of lactate sensitivity for the phenomenon of panic attacks and gives further evidence for biological differences between panic and depression.
输注乳酸钠会诱发惊恐障碍患者的惊恐发作，但不会诱发正常对照者的惊恐发作。我们之前已经表明，在重度抑郁发作期间出现惊恐障碍的患者，在乳酸诱发惊恐发作的发生率方面与惊恐障碍患者相似。在本初步研究中，9名无惊恐发作的重度抑郁症患者接受了乳酸输注。这些患者在对乳酸的反应上与惊恐障碍患者有显著差异，但与对照者无差异。这表明乳酸敏感性对于惊恐发作现象具有特异性，并进一步证明了惊恐障碍与抑郁症之间的生物学差异。
