一种氟化抗精神病药物配体的19F磁共振成像与波谱分析：体内和体外研究

19F magnetic resonance imaging and spectroscopy of a fluorinated neuroleptic ligand: in vivo and in vitro studies.

作者信息

Arndt D C, Ratner A V, Faull K F, Barchas J D, Young S W

机构信息

Nancy Pritzker Laboratory of Behavioral Neurochemistry, Stanford University Medical School.

出版信息

Psychiatry Res. 1988 Jul;25(1):73-9. doi: 10.1016/0165-1781(88)90160-6.

DOI:10.1016/0165-1781(88)90160-6

PMID:3217469

Abstract

The bulk biodistribution of a trifluorinated neuroleptic (fluphenazine) was studied using 19F magnetic resonance imaging (MRI). Fifteen male Sprague-Dawley rats were injected with fluphenazine (120 mg/kg) and scanned in a G.E. CSI 2.0 tesla MRI system. The rats were killed following scanning and the brains were removed. The excised brains were then scanned using 1H and 19F MR techniques. The fluorinated neuroleptic was imaged at the injection site, spectroscopically detected in vivo in the head, and spectroscopically localized in the whole brain. These data suggest that in vivo 19F MRI of fluorinated agents is possible and could have clinical and research applications to the neurosciences.

摘要

使用19F磁共振成像（MRI）研究了一种三氟代抗精神病药物（氟奋乃静）的整体生物分布。给15只雄性斯普拉格-道利大鼠注射氟奋乃静（120 mg/kg），并在通用电气公司的CSI 2.0特斯拉MRI系统中进行扫描。扫描后处死大鼠并取出大脑。然后使用1H和19F MR技术对切除的大脑进行扫描。在注射部位对氟化抗精神病药物进行成像，在头部进行体内光谱检测，并在整个大脑中进行光谱定位。这些数据表明，对氟化剂进行体内19F MRI是可行的，并且在神经科学的临床和研究应用中可能具有应用价值。